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Update on Geographic Atrophy and Complement System–based Therapeutics

By: Peter K. Kaiser, MD (Moderator); Prof. Frank G. Holz, MD; Arshad Khanani, MD, MA; Prof. Anat Loewenstein, MD, MBA; Prof. Jordi Monés, MD, PhD

This course has expired. You can still review the content but course credit is no longer available.

Supplement Credits: 1

This continuing medical education (CME) activity captures content from a virtual roundtable discussion.

ACTIVITY DESCRIPTION
The impact on quality of life for patients with geographic atrophy (GA) is significant. This supplement reviews the prevalence of age-related macular degeneration (AMD), including advanced AMD (exudative and GA) as well as the pathogenesis of GA and the complex role of the complement system in GA development. The faculty members also discuss the latest clinical trial data for pipeline candidates targeting the complement pathways for the treatment of GA.

This certified CME activity is designed for retina specialists who treat patients with retinal diseases.

Expiration Date: Friday, September 30, 2022
Release Date: September 1, 2021

Learning Objectives

Upon completion of this activity, the participant should be able to:

  • Describe the prevalence of advanced AMD, including advanced AMD (exudative and GA)
  • Explain the pathogenesis of GA
  • Understand the complex role of complement system in GA development
  • Outline pipeline candidates targeting the complement pathways that are under investigation for the treatment of GA

Accreditation and Designation Statement

Provided by Evolve Medical Education LLC (Evolve).

Evolve is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Evolve Medical Education designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participation Method

In order to obtain credit, proceed through the program, complete the post-test, evaluation and submit for credit.

Course Viewing Requirements

Supported Browsers:
Internet Explorer 11 for Windows
Edge (recent versions; Chromium-based) for Windows
Google Chrome (recent versions) for Windows, Mac OS, iOS, Android, or Linux
Mozilla Firefox (recent versions) for Windows, Mac OS, iOS, Android, or Linux
Safari (recent versions) for Mac OSX, or iOS

Hardware Requirements:
4GB+ RAM
Recommended internet speed 5Mbps+

Faculty and Disclosures

Peter K. Kaiser, MD (Moderator)

Professor of Ophthalmology
Cleveland Clinic Lerner College of Medicine
Chaney Family Endowed Chair in Ophthalmology Research
Cole Eye Institute
Cleveland, OH

Prof. Frank G. Holz, MD

Director
Institut de la Macula
Director and Principal Investigator
Barcelona Macula Foundation
Barcelona, Spain

Arshad Khanani, MD, MA

Director of Clinical Research
Sierra Eye Associates
Clinical Associate Professor
University of Nevada
Reno School of Medicine
Reno, Nevada

Prof. Anat Loewenstein, MD, MBA

Director, Division of Ophthalmology
Tel Aviv Medical Center
Vice Dean, Sackler Faculty of Medicine
Tel Aviv University
Tel Aviv, Israel

Prof. Jordi Monés, MD, PhD

Director
Institut de la Macula
Director and Principal Investigator
Barcelona Macula Foundation
Barcelona, Spain

DISCLOSURE POLICY
It is the policy of Evolve that faculty and other individuals who are in the position to control the content of this activity disclose any real or apparent conflicts of interest relating to the topics of this educational activity. Evolve has full policies in place that will identify and mitigate all conflicts of interest prior to this educational activity.

The following faculty/staff members have the following financial relationships with commercial interests:

Peter K. Kaiser, MD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: Aerie Pharmaceuticals, Aerpio, Alcon Vision, Allegro Ophthalmics, Allergan, Bayer, Bausch + Lomb, Biogen Idec, Boehringer Ingelheim, Clearside Biomedical, Eyevensys, Galecto, Galimedix, iRenix, jCyte,Kanghong Biotech, Kodiak Sciences, NGM Biopharmaceuticals, Novartis, Omeros, Ophthea, Ophthotech, Oxurion, Regeneron Pharmaceuticals, RegenexBio, Retinal Sciences, Santen, SciFluor, Shire, Stealth Biotherapeutics, and Verena. Grant/Research Support: National Eye Institute, National Institute of Health and Research to Prevent Blindness. Speaker’s Bureau: Allegro Ophthalmics, Clearside Biomedical, Ophthotech, Retinal Sciences, and Verena.

Prof. Frank G. Holz, MD, has had no agreements or affiliation during the past year with commercial interests.

Arshad Khanani, MD, MA, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: Adverum, Aerpio, Alcon Vision, Allergan, Dutch Ophthalmic Research Center, Genentech, Iveric Bio, Kato Pharmaceuticals, Kodiak Sciences, Novartis, Gemini Therapeutics, Graybug, Gyroscope, Opthea, Oxurion, PolyPhotonix, Recens Medical, and Regenxbio. Grant/Research Support: Adverum, Alkahest, Allergan, Allegro, Gemini Therapeutics, Genentech, Gyroscope, Iveric Bio, NGM pharmaceuticals, Kodiak Sciences, Novartis, Opthea, Oxurion, Regenxbio, and Recens Medical. Speaker’s Bureau: Allergan, Genentech, and Novartis.

Prof. Anat Loewenstein, MD, MBA, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: Allergan, Bayer, Beyeonics, KHB, Novartis, Notal Vision, Roche, Syneos Health, and WebMD. Grant/Research Support: Allergan, Bayer, and Novartis.

Prof. Jordi Monés, MD, PhD, has had a financial agreement or affiliation during the past year with the following commercial interests in the form of Consultant: Apellis, CellCure, Iveric Bio, Kodiak, Novartis, Reneuron, and Roche. Grant/Research Support: Apellis, Iveric Bio, Gyroscope, Novartis, and Roche. Stock/Shareholder: Iveric Bio and Notal Vision.

The Evolve staff and planners have no financial relationships with commercial interests. Michelle Dalton, writer, and Nisha Mukherjee, MD, peer reviewer, have no financial relationships with commercial interests.

Disclaimer

OFF-LABEL STATEMENT
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The opinions expressed in the educational activity are those of the faculty. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

DISCLAIMER
The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Evolve, Retina Today, or Iveric Bio.

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