CME Event: 3rd Annual CSF Disorders Symposium

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Overview / Abstract:

Over 200 disorders impact connective tissue. Those are genetic
disorders, such as Ehlers-Danlos syndrome, Marfan syndrome,
and autoimmune disorders, such as lupus and scleroderma. Ehlers-
Danlos syndromes (EDS), including the associated hypermobility
spectrum disorders (HSDs), previously classified as EDS type III, are
the most commonly observed, and the neurological manifestations
include effects on the Cerebrospinal fluid circulation. This has been
largely overlooked and poorly described.
In 2017, for the first-time management and care guidelines have
been produced for the co-morbidities that can occur within EDS and
HSDs (1) supported by the international Ehlers-Danlos society (2).
Experts and physicians treating patients with EDS, more frequently
and uniquely observe neurological manifestations that ought to be
linked to the pathophysiology of deficient collagen, hypermobility,
unstable vertebra and early disk disease, and an aroused immune
system. All those deficiencies may cause structural and functional
problems to the central nervous system, such as compression and
stretch of the brain stem and spinal cord at the base of the skull due
to instability and a hyperflexible spine, chronic cerebrospinal fluid
leak and occult tethered cord syndrome (OCTS). Further, mediation
of systemic inflammatory and immune reaction to the brain tissue,
that may promote the neurological sequalae and symptoms, such as
pain, extremity weakness and sensory deficits, bladder and bowel
dysfunction and dysautonomia and cognitive complains. There are
viable surgical options and interventions, i.e. stabilization of the
skull base and spine, decompression of the skull base or surgical
resection of the filum terminale to “release” the stretching of the
spinal cord. Those interventions in the expert’s hands have shown to
ameliorate the above listed symptoms, however, this specialized field
is in the pioneering stage and a controversial topic.
The CSF symposium will discuss and advance the understanding
of the above with focus on the most prevalent Ehlers-Danlos
syndromes, and provide both clinical and translational evidence
to the concept of central nervous and cerebrospinal fluid system
manifestations of connective tissue syndromes based in imaging,
pathological findings and results of pain, physical therapy and
surgical interventions.


Jun 17, 2018


Nurse Practitioner , Nursing CNE, Physical Therapy CE, Physician CME, Physician Assistant CME



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Keywords / Search Terms

The Warren Alpert Medical School of Brown University csf, cme, accme, rhode island, alpert medical school, brown university, ehlers danlos, marfan, autoimmune Live CE CME Seminar CE CME

LIVE Activity Location Details


Warren Alpert Medical School of Brown University
222 Richmond Street
Providence, RI   02912
United States of America

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