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Indiana University School of Medicine

Examining Recent Evidence Supporting DOAC Use in the Reduction of Thrombotic Events in Diverse Cardiovascular Patients

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Overview / Abstract:

In this clinical commentary, a panel of three faculty experts review clinical data on the use of DOACs for vascular protection in patients with cardiovascular disease. The discussion will provide an in-depth analysis of safety and efficacy data on prophylactic DOAC use for reducing and/or preventing thrombotic events in patients with atherosclerotic disease. The discussion will also examine recently published trial data and interpret potential implications of these findings in the context of complex, diverse patient populations.

This activity is intended for cardiologists and other healthcare providers who care for patients with atherosclerotic disease.

Patients who experience a cardiovascular event or have peripheral artery disease require long-term antithrombotic prophylaxis to reduce the risk of recurrent cardiac events. Formulating complex regimens for secondary prevention of subsequent cardiovascular events and improved long-term cardiovascular outcomes poses a significant clinical challenge, and patients continue to experience events and associated mortality. The purpose of this activity is to review past and current clinical trial evidence investigating anticoagulant use in the reduction of thrombotic events in diverse cardiovascular patients.

Upon completion of this activity, participants will be able to:
• Discuss long-term atherothrombotic risks in patients with stable cardiovascular disease, including coronary artery disease and peripheral arterial disease
• Interpret data from recent clinical trials using antithrombotic therapy for vascular protection
• Formulate comprehensive pharmacological regimens for complex, diverse patient populations


Feb 22, 2019


Nurse Practitioner , Nursing CNE, Physician CME, Physician Assistant CME, Radiology / RAD Tech CE, Surgical Technology CE


New Procedures, Online, Webinar / Webcast / Video

Credits / Hours




Is This Activity Certified for "Live" Credit?


Presenters / Authors / Faculty

Christian T. Ruff, MD, MPH (Chair)
Assistant Professor of Medicine
Harvard Medical School
Investigator, TIMI Study Group
Cardiovascular Division
Brigham and Women’s Hospital
Boston, MA

Joshua A. Beckman, MD, Msc.
Professor of Medicine
Director, Vascular Medicine
Cardiovascular Division
Vanderbilt University Medical Center
Nashville, TN

Marc P. Bonaca, MD, MPH
Assistant Professor of Medicine
Harvard Medical School
Investigator, TIMI Study Group
Brigham and Women’s Hospital
Boston, MA

Activity Specialities / Related Topics

Anticoagulation / Thrombosis, Cardiology / Cardiovascular, Critical Care / Intensive Care, Diagnosis / Assessment / Patient History, Emergency Medicine, Family Medicine, Hematology, Internal Medicine, Podiatry, Primary Care

Sponsors / Supporters / Grant Providers

Supported by an educational grant from Janssen Scientific Affairs, LLC.

Keywords / Search Terms

ACHL DOAC, DOACs, NOACs, NOAC, NOAC reversal, DOAC reversal, anticoagulants, anticoagulation, Christian Ruff, Marc Bonaca, Josh Beckman, venous thromboembolism, VTE, thrombosis, Oral anticoagulation, Atrial fibrillation, Stroke, Venous thromboembolism, Bleeding Free CE CME Live CE CME

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