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Getting to Remission: Differentiating Residual Symptoms from Treatment Side Effects in Major Depressive Disorder

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Overview / Abstract:

Millions of US adults with MDD are inadequately treated despite the availability of effective therapies. Achieving and maintaining remission continues to be a considerable clinical challenge. In addition, cognitive impairment is a common residual symptom, and many clinicians are failing to assess for and manage this aspect of depression. Some residual symptoms, such as weight gain, sleep disturbances, and sexual dysfunction, may be difficult to distinguish from treatment side effects. Despite these challenges, there are strategies to address obstacles to remission and return to full functioning in MDD. Efforts to go beyond response are crucial, as failure to achieve remission can lead to greater risk of relapse, functional limitations, social and vocational impairment, cognitive impairment, increased risk of suicide, and elevated health care costs. Education can help health care providers enhance their ability and confidence in helping patients achieve remission. This activity was designed to meet the needs of participants in CME activities provided by the CME Institute of Physicians Postgraduate Press, Inc., who have requested information on MDD.

Learning Objectives
After completing this educational activity, you should be able to:

Evaluate patients being treated for depression to identify the presence of residual symptoms
Identify and manage residual cognitive impairment in patients with depression
Implement strategies to differentiate residual symptoms of depression from adverse effects of antidepressants


Dec 14, 2019


Counselor CE, Nurse Practitioner , Nursing CNE, Physician CME, Physician Assistant CME, Psychology CE, Social Work CE



Credits / Hours




Presenters / Authors / Faculty

Roger S. McIntyre, MD, FRCPC

Activity Specialities / Related Topics

Sexual Issues, Psychiatry / Mental Health, Primary Care, Geriatrics / LTC, Depression / Bipolar, Counseling, Case Management

Sponsors / Supporters / Grant Providers

Takeda Pharmaceuticals U.S.A., Inc. and Lundbeck

Keywords / Search Terms

CMEology major depressive disorder, MDD, MDD Residual symptoms, psychiatry, physician, physician assistant, CME, depression, side effects Free CE CME

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