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EXCEL Continuing Education

FGF23, X-Linked Hypophosphatemia (XLH) and Tumor-Induced Osteomalacia (TIO): Emerging Treatments

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Overview / Abstract:

X-linked hypophosphatemia (XLH) is an inherited, lifelong disease of phosphate metabolism in which inactivating mutations of the PHEX gene causes a loss of phosphate wasting and leads to an increased concentration of fibroblast growth factor 23 (FGF23), which regulates the reabsorption of phosphate in the kidneys. Simply stated, XLH is known for increased secretion of FGF-23, which leads to hypophosphatemia and consequently osteomalacia, rickets, and skeletal deformities.

The principle acquired form of FGF23-mediated hypophosphatemia is tumor-induced osteomalacia (TIO), a rare disease characterized by the development of phosphaturic mesenchymal tumors (PMTs) that are typically non-malignant and slow-growing.

This accredited activity intends to close knowledge and practice gaps by addressing the link between both disorders. Devising treatment plans that incorporate the latest developments in the management of these disorders will also be addressed.

Expiration

Oct 21, 2021

Discipline(s)

Nurse Practitioner , Nursing CNE, Physician CME, Physician Assistant CME

Format

Webinar / Webcast / Video

Credits / Hours

1

Accreditation

ACCME

Presenters / Authors / Faculty

Kathryn M. Dahir, MD
Professor of Medicine
Vanderbilt University Medical Center
Program for Metabolic Bone Disorders
Endocrinology and Diabetes
Nashville, TN

Activity Specialities / Related Topics

Endocrinology, Genetics, Pathology, Pediatrics, Perinatology, Primary Care, Radiology / Imagery / Nuclear Medicine, Surgery

Sponsors / Supporters / Grant Providers

Ultragenyx Pharmaceuticals

Keywords / Search Terms

EXCEL Continuing Education phosphate disorders, rickets, tumor-induced osteomalacia, hypophosphatemia, FGF-23. Free CE CME

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