Advances In™ Monogenic Kidney Disorders: Optimizing Diagnosis and Management in Pediatric & Adult Patients

Target Audience
This online educational activity is directed toward adult and pediatric nephrologists, urologists, advanced practice clinicians, and medical specialists who treat monogenic kidney stone disorders, including PH1. Nurses and other healthcare professionals who would be involved in the diagnosis and management of PH1 will be invited to participate.

Program Overview
Monogenic kidney stone disorders include cystinuria, primary hyperoxaluria, and Dent disease. These diseases are characterized by urinary hyperexcretion of insoluble mineral salts, leading to recurrent kidney stones or increased renal calcium deposition. Patients with rare stone diseases are more likely to develop chronic kidney disease, which can progress to end-stage renal disease (ESRD). Failure to recognize these diseases may lead to diagnostic delays and preventable renal injury. In the past few years, studies have identified the clinical importance of determining if a patient’s cause of kidney stone disease is genetic. Studies suggest that 15% of patients who seek specialty care for their kidney stones and 30% of those younger than 25 years of age with recurring stones have a monogenic form of nephrolithiasis.

This program reviews the etiology, pathophysiology, presentation, and diagnosis of monogenic kidney stone disease and aims to increase clinicians’ knowledge of the current and emerging treatment options for patients with monogenic kidney stone disorders.

Learning Objectives
Upon completion of this activity, participants should be better able to:

Review the etiology and pathophysiology of monogenic kidney stone disorders
Examine the symptomatology, clinical presentation, and diagnosis of monogenic kidney stone disorders
Analyze the latest data on the efficacy and safety of the management of kidney stone disorders and the evolving treatment options