Is Colchicine the 2020 Comeback Kid?

Colchicine has been used in medicine for > 2000 years and current established uses include treatment of gout, Familial Mediterranean Fever, and pericarditis, although it has been studied in a wide range of conditions including atrial fibrillation, cancer, and more recently prevention of ischemic events in patients with coronary heart disease. Despite lifestyle changes and significant advances in medicine and interventional cardiology, patients with coronary heart disease remain at high risk for cardiovascular events creating a continued focus on measures to mitigate risk. Will colchicine comeback to fame and help mitigate cardiovascular adverse events?