Unraveling the Complexity of Severe Asthma Treatment

Target Audience
This activity is designed to meet the educational needs of Pulmonologists, Allergists, Nurse Practitioners and Physician Assistants in those specialties.

Program Overview
The past two decades of research in severe asthma have changed our understanding of this complex, heterogeneous condition that includes a host of inflammatory subtypes and clinical manifestations with variations in endotype, phenotype and biomarkers/cytokines. Newly approved and emerging therapies that target the epithelial alarmins represent an important opportunity to improve outcomes for patients with a broad range of asthma phenotypes.

This activity will unravel the complexity of severe asthma treatment by providing expert insights into the new paradigm of treatments. Topics include the role of the epithelium in severe asthma, the downstream effect on alarmins, airway hyperrresonsiveness, and matching phenotypes to therapeutic approaches for improved patient care.

Learning Objectives
Upon completion of this activity, participants should be better able to:

Describe the role of the airway epithelium in asthma.
Define the epithelial alarmins and their impact on T2 and non-T2 airway inflammation, remodeling, and hyper responsiveness in severe asthma.
Evaluate the results of clinical trials of current and emerging therapies that target the epithelial alarmins in severe asthma.
Match clinical characteristics and phenotypes to treatment targets.