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The Oncologist: Efficacy and Safety of Everolimus in Extrapancreatic Neuroendocrine Tumor: A Comprehensive Review of Literature
Learning Objectives:
1. Describe the use of everolimus in clinical practice.
2. Discuss the possibility of using everolimus in neuroendocrine tumors other than pancreatic.
3. Recount the safety profile of everolimus.
Background.
Everolimus, an oral mTOR (mammalian target of rapamycin) inhibitor, is currently approved for the treatment of progressive pancreatic neuroendocrine tumors (NETs). Although promising, only scattered data, often from nondedicated studies, are available for extrap... |
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Gastrointestinal Pathology - Masters of Pathology Series: The Oakstone Institute Specialty Review
Topics covered in Gastrointestinal Pathology include:
Anal Pathology, Barrett's Esophagus, Colorectal Neoplasms, Gastric Neoplasms, Appendix Pathology, Mesenchymal Tumors, Nonneoplastic Colorectal Pathology, Polyposis Syndromes, Small Intestinal Neoplasms and many others.
Viewing Gastrointestinal Pathology will help you to better:
• Discuss the most recent histopathological classifications of various gastrointestinal polyps and neoplasms currently recognized by the WHO in all areas of the... |
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Pathology CME Online Bundle: Three Review Programs - Journal Summaries - $1,000 Amazon.com Gift Card
The Pathology CME Online Bundle features:
• From CMEinfo - Three specialty reviews with 49 lectures covering topics in dermatopathology, gastrointestinal and breast pathology
• From Practical Reviews - A one-year subscription, including the FREE mobile app
• A $1,000 Amazon.com gift card
Topics include:
Melanoma, Neoplastic Dermatopathology, Alopecia, Melanocytic Lesions, B cell Lymphomas, Nonneoplastic Colorectal Pathology, Polyposis Syndromes, Small Intestinal Neoplasms, Invas... |
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The Oncologist: Location of Primary Tumor and Benefit From Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer
Learning Objectives:
1. Explain the differences between right- and left-sided colorectal cancer in terms of clinical and molecular characteristics.
2. Describe the response of RAS and BRAF wild-type right-sided colorectal cancer to anti-EGFRs.
Introduction.
Right- and left-sided colorectal cancers (CRCs) differ in clinical and molecular characteristics. Some retrospective analyses suggested that patients with right-sided tumors derive less benefit from anti-epidermal growth factor recept... |
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The Oncologist: A Randomized Controlled Trial of a Nurse-Led Supportive Care Package (SurvivorCare) for Survivors of Colorectal Cancer
Learning Objectives:
1. Discuss the range of issues that survivors of colorectal cancer may experience.
2. Critically review interventions and models of care that aim to better meet the needs of survivors.
3. Critically review endpoints for studies that aim to improve the wellbeing of survivors and recognize challenges with study endpoints.
Introduction.
Colorectal cancer (CRC) and its treatments can cause distressing sequelae. We conducted a multicenter randomized controlled trial aimi... |
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The Oncologist: Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy
Learning Objectives:
1. Evaluate outcomes data relating to the previous use of metformin in patients with advanced colorectal cancer receiving adjuvant FOLFOX therapy
2. Compare outcomes data relating diabetic and non-diabetic patient with advanced colorectal cancer receiving adjuvant FOLFOX therapy
Background.
Preclinical and epidemiological data suggest that metformin might have antineoplastic properties against colon cancer (CC). However, the effect of metformin use on patient surviva... |
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Improving Colorectal Cancer Prevention: Latest Advances to Improve Adenoma Detection Rates
Colorectal cancer (CRC) is the third most common type of cancer worldwide and second deadliest form of cancer in the United States. Current estimates suggest that up to 25% of adenomas are missed with current colonoscopy technologies, primarily due to poor visualization in folds and other difficult-to-detect areas. Technological advances in recent years have improved detection rates. This CME activity will review appropriate screening and prevention efforts for the early detection of patients ... |
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Checkpoint Inhibitors in Gastrointestinal Tumors: The Latest Evidence on Safety, Efficacy, and Biomarkers
The genomes of cancers deficient in mismatch repair (MMR) contain extremely high numbers of somatic mutations. Analysis of recent clinical studies have demonstrated that colorectal cancers with mismatch repair deficiency (dMMR) and other advanced dMMR cancers are sensitive to immune checkpoint blockade with PD-1 antibodies, and that mutational burden correlates with treatment response. These findings have led to the recent approval of two immune checkpoint inhibitors for the treatment of micro... |
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Cancer Screening in the United States, 2017: A Review of Current American Cancer Society Guidelines and Current Issues in Cancer Screening
After reading the article “Cancer Screening in the United States, 2017: A Review of Current American Cancer Society Guidelines and Current Issues in Cancer Screening,” the learner should be able to:
Discuss American Cancer Society guidelines for early detection of breast, colorectal, cervical, lung, and prostate cancers.
Provide patients with guidance and recommendations about appropriate early cancer detection options.
Relate about new and emerging cancer detection technologies. |
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The Oncologist: A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer – Alliance (CALGB) 9581 and 89803
Learning Objectives:
1. Describe the association between tumor levels of thymidylate synthase and outcomes in patients with resected colon cancer treated with adjuvant therapy
2. Discuss the value of thymidylate synthase levels in predicting treatment benefits of 5-fluorouracil in patients with resected colon cancer
Purpose.
Tumor levels of thymidylate synthase (TS), a target of 5‐fluorouracil (5‐FU)‐based chemotherapy for colorectal cancer, have been studied as a predictive or pro... |
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Improving Metastatic Colorectal Cancer (mCRC) Care in Community Cancer Centers
The clinical management of patients with metastatic colorectal cancer (mCRC) continues to evolve as advances in research lead to new approaches in molecular biomarker testing and the application of treatment plans that are tailored for each patient. The goal of this program is to educate and enable members of the cancer care team to apply the latest guidelines and evidence when managing patients with mCRC. |
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New Drugs Approved in 2015
In 2015, the FDA’s Center for Drug Evaluation and Research (CDER) approved 45 new molecular entities – the highest annual number of new drugs to be approved in the past decade (up from 41 in 2014). The new approvals include 16 first-in-class drugs spanning 14 different medical conditions. Many of the new drugs were approved under one or more of the FDA’s 4 expedited pathways (fast track, breakthrough, priority review, and accelerated approval). Nearly half are for the treatment of rare d... |
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UCSF Abdominal and Thoracic Imaging: University of California San Francisco Clinical Update
Topics covered by UCSF Abdominal and Thoracic Imaging include:
Acute Chest Cases, Coronary CTA. The Post-Operative Aorta , Adnexal Masses on Ultrasound, Kidney Stone, Retroperitoneal Masses, Colorectal Cancer Screening, Mediastinal Masses, Pediatric Appendicitis Ultrasound and many more.
After viewing UCSF Abdominal and Thoracic Imaging, you will be better able to:
• Manage the acute aorta and common cardiovascular abnormalities
• Apply current consensus on pulmonary nodules, lung canc... |
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UCSF Abdominal & Pelvic Imaging: CT/MR/US
Topics covered by UCSF Abdomen & Pelvic Imaging include:
CT/MRI of Adrenal Glands, Imaging of Pancreatic Cancer, Assessment of Diffuse Liver Disease, Imaging of Renal Tumors, CT Urography, Imaging of Adnexa, Acute Pelvic Pain, Pancreatitis and many others.
After completing UCSF Abdomen & Pelvic Imaging, you should be better able to:
• Apply the ACR recommendations for managing incidental CT-scan findings in the kidney, liver, adrenal gland and pancreas
• Identify indications for the us... |
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The University of Chicago Digestive Diseases Review: University of Chicago Medicine & Biological Sciences Specialty Review (SA-CME)
Studying the University of Chicago Digestive Diseases Review will help you to better:
• Keep up with the latest advancements regarding the biology and treatment of patients with digestive diseases
• Apply new knowledge in GI, hematology, and nutrition with this review in gastroenterology
• Integrate current guidelines into daily practice when preventing and managing digestive diseases |
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Osler Radiation Oncology Online Review
The Osler Institute utilized state of the art equipment to record the comprehensive Radiation Oncology Review Course and bring it to you! These audio files are stored “in the cloud” so you can stream them anywhere, anytime, as long as you have an internet connection – your learning experience is almost like being at the live activity, but without travel costs and time away from your practice. The Osler Radiation Oncology Review also offers a variety of live Radiation Oncology board revie... |
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Osler General Surgery Online Video Review
Topics covered by the Osler General Surgery Online Video Review include:
Abdominal Wall and Hernia, Gastric Surgery, Gastrointestinal Bleeding, Liver and Gallbladder, Pancreatic Surgery, Spleen, Colorectal Surgery, Head and Neck Surgery, Esophageal Surgery, Thoracic Surgery, Breast Surgery, Vascular Surgery, Endocrine Surgery, Pediatric Surgery, Trauma, Critical Care. Osler General Surgery also offers a variety of live General Surgery board review meetings as well as a number of text-based Ge... |
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Osler Surgery MOC Online Review
Topics coverd by Osler Surgery MOC Online Review include: Thyroid, Parathyroid, Multiple Endocrine Neoplasia, Adrenal, Gastric Neoplasia, Skin and Melanoma, Appendix-Small Bowel- Spleen, Sarcoma, Nutrition, Acid-Base, Fluids and Electrolytes, Anorectal and Colorectal Disorders, Colorectal Neoplasia, Gastric Bleeding, Stomach and Duodenum, Esophageal Surgery, Biliary and Liver, Pancreas and Portal Hypertension, Mediastinum and Chest Wall, Pulmonary Surgery, Breast Surgery, Abdominal Wall and He... |
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Osler Surgery MOC Online Review
The Osler Institute utilized state of the art equipment to record the comprehensive Radiation Oncology Review Course and bring it to you! These audio files are stored “in the cloud” so you can stream them anywhere, anytime, as long as you have an internet connection – your learning experience is almost like being at the live activity, but without travel costs and time away from your practice. The Osler Radiation Oncology Review also offers a variety of live Radiation Oncology board revie... |
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