i3 Health

i3 Health


Appraisal of Recent Progress in Metastatic Castration-Resistant Prostate Cancer: Current Trends and Future Directions

STATEMENT OF NEED Prostate cancer is the most common tumor type in the United States. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be underst...
University of Cincinnati and i3 Health

Best Practices in Nursing Management of Chemotherapy-Induced Peripheral Neuropathy

STATEMENT OF NEED Chemotherapy-induced peripheral neuropathy (CIPN) is a complication of cancer treatment that may impair quality of life and lead to treatment dose reductions or discontinuation in severe cases. In one study of 123 patients receiving taxane therapy for breast cancer, 17% required dose reductions because of CIPN (Bhatnagar et al, 2014). Whereas in some patients the symptoms of...
i3 Health

Defining Personalized Care Plans in Metastatic Castration-Resistant Prostate Cancer

STATEMENT OF NEED Prostate cancer is the most common tumor type among men in the United States. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to ...
Postgraduate Institute for Medicine and i3 Health

Management of Cancer Pain: Current Guidelines

STATEMENT OF NEED Cancer patients often experience a range of symptoms that negatively impact their quality of life. Among the most debilitating is pain. Despite efforts to increase awareness, cancer pain is still underdiagnosed and undertreated and patients do not obtain complete relief. Although numerous management guidelines for cancer pain have been developed, most health care practitione...
i3 Health

Management of Venous Thromboembolism in Ambulatory Patients With Cancer

STATEMENT OF NEED Venous thromboembolism (VTE) is a common and potentially life-threatening complication in patients with cancer. There are two main types of VTE: deep vein thrombosis (DVT) and pulmonary embolus (PE), which can cause right heart failure, cardiopulmonary collapse, and death (Ozaki & Bartholomew, 2012). Patients who develop PE require hospitalization, increased oxygen requireme...
i3 Health

Management of Venous Thromboembolism in Hospitalized Patients With Cancer

STATEMENT OF NEED Venous thromboembolism (VTE), which consists primarily of deep vein thrombosis (DVT) and pulmonary embolism (PE), is a life-threatening complication in hospitalized patients with cancer, and is associated with a 2- to 6-fold increase in likelihood of death (NCCN, 2016). The mainstay of treatment is anticoagulation; however, since cancer patients with VTE have higher rates of...
i3 Health

Nursing Management of Cancer Treatment-Induced Cardiotoxicity

STATEMENT OF NEED Several studies reveal that certain cancer therapies adversely affect the heart and lead to various types of injuries, which often result in death. Adverse cardiac effects may occur immediately after cessation of therapy or, in some cases, years after the therapy has been discontinued. Often the cardiotoxicity presents in subtle ways, and a lack of awareness results in high ...
i3 Health

Optimizing Management of Carcinoid Syndrome in Patients With Neuroendocrine Tumors

STATEMENT OF NEED Carcinoid syndrome refers to a constellation of symptoms caused by the systemic release of humoral factors such as polypeptides, biogenic amines, and prostaglandins, mostly from well-differentiated neuroendocrine tumors. Patients frequently experience flushing, abdominal cramps, bronchospasms, hypotension, and diarrhea, which lead to impaired quality of life and daily functi...
Postgraduate Institute for Medicine and i3 Health

Optimizing Nursing Management of Hepatic Veno-Occlusive Disease

STATEMENT OF NEED Veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a potentially life-threatening complication of hematopoietic stem cell transplant (HSCT), characterized by weight gain, fluid retention with ascites, tender hepatomegaly, and jaundice. The toxicity is believed to result from damage to hepatic sinusoidal endothelial cells, which causes obstructed ...
i3 Health

Preventing and Mitigating Chemotherapy-Induced Nausea and Vomiting in High-Risk Patients

STATEMENT OF NEED The introduction of effective antiemetic regimens in recent years has led many clinicians to assume that CINV is no longer a major problem. However, nausea and vomiting are frequent complications of cancer treatment, occurring in up to 80% of patients receiving chemotherapy. Furthermore, wide gaps exist between patient and provider perceptions of nausea and vomiting. Clinici...
Postgraduate Institute for Medicine and i3 Health

Prevention of Medical Errors in Nursing Practice

STATEMENT OF NEED Medical errors are among the most common health-threatening mistakes that affect patient care, accounting for as many as 250,000 deaths per year in the United States (Makary & Daniel, 2016). Medical errors are considered a global problem, complicating a patient’s primary condition for which they needed medical attention. These errors can lead to adverse outcomes such as incr...
i3 Health

Selecting Optimal Antiangiogenic Strategies for Patients With Hepatocellular Carcinoma

STATEMENT OF NEED Hepatocellular carcinoma is the sixth most common tumor globally, with an increasing incidence in the United States and Europe. The malignancy is the third leading cause of cancer-related death worldwide and the leading cause of death in patients with cirrhosis. Approximately 40,710 new cases are diagnosed in the United States annually and 28,920 people die of the disease. P...
Postgraduate Institute for Medicine and i3 Health

Selecting Optimal Therapeutic Strategies for Patients With Differentiated and Medullary Thyroid Cancer

STATEMENT OF NEED Thyroid cancer is one of the most prevalent cancers in the United States. An estimated 56,870 new cases are diagnosed annually, and 2,010 people die of the disease (ACS, 2017). Thyroid cancer is typically more aggressive in men than women and becomes increasingly lethal in those older than age 40 (NCCN, 2016). There are three primary subtypes: differentiated (including papil...
Penn State College of Medicine and i3 Health

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