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Best Practices in Nursing Management of Chemotherapy-Induced Peripheral Neuropathy
STATEMENT OF NEED
Chemotherapy-induced peripheral neuropathy (CIPN) is a complication of cancer treatment that may impair quality of life and lead to treatment dose reductions or discontinuation in severe cases. In one study of 123 patients receiving taxane therapy for breast cancer, 17% required dose reductions because of CIPN (Bhatnagar et al, 2014). Whereas in some patients the symptoms of...
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Challenges and Opportunities in Hodgkin Lymphoma
STATEMENT OF NEED
Hodgkin lymphoma (HL) is a rare malignancy involving the lymph nodes and lymphatic system, with 8,500 new cases diagnosed and accounting for 1,050 deaths each year in the United States. In contrast with other cancers whose risk increases with age, the risk for HL increases in patients between 15 and 30 years of age, decreases during middle age, and is followed by another pea...
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Challenges and Opportunities in Metastatic Gastric Cancer
STATEMENT OF NEED
Gastric cancer is the third leading cause of cancer-related death worldwide. In the US, an estimated 27,510 new cases of gastric cancer are diagnosed annually, and 11,140 people die of the disease. Despite advances in prevention, diagnosis, and treatment, due to the molecular heterogeneity of gastric cancer, prognosis remains poor. The 5-year survival rate for all stages is ...
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Current Challenges and New Opportunities in Follicular Lymphoma
STATEMENT OF NEED
Of the estimated 74,680 new cases of non-Hodgkin lymphoma each year in the United States, approximately 35% are follicular lymphoma (FL), an indolent, difficult-to-treat B-cell malignancy. Most patients are diagnosed at an average age of 65 years. Despite the introduction of novel therapies during the past decade, complications such as delayed presentation and treatment and ...
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Current Trends and Future Directions in Targeted Therapies for Advanced Renal Cell Carcinoma
STATEMENT OF NEED
Based on recent estimates, kidney cancer accounts for approximately 4% of all cancer diagnoses in the United States. An estimated 65,300 new cases are reported each year and more than 14,000 people die of the disease. Renal cell carcinoma (RCC), which comprises nearly 90% of all kidney cancers, is characterized by a lack of early warning signs, diverse clinical manifestation...
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Current Trends in the Management of Castration-Resistant Prostate Cancer
STATEMENT OF NEED
Prostate cancer is the most common tumor type in men in the United States. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be ...
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Implementing New Data and Evolving Standards in Metastatic Triple-Negative Breast Cancer
STATEMENT OF NEED
Breast cancer accounts for approximately 30% of cancer diagnoses among women in the United States and is the second-leading cause of cancer death in this population. About 20% of patients have invasive triple-negative breast cancer (TNBC), which is defined as having estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) negati...
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Improving Treatment Outcomes of Patients With Waldenstrom Macroglobulinemia
STATEMENT OF NEED
Waldenstrom macroglobulinemia (WM) is a rare lymphoproliferative disorder characterized by lymphoplasmacytic bone marrow infiltration and the presence of serum monoclonal IgM. With an estimated 1,500 new cases reported in the United States annually, the malignancy accounts for 2% of non-Hodgkin lymphomas. Unfortunately, WM is considered incurable with available therapies. Pa...
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Management of Venous Thromboembolism in Ambulatory Patients With Cancer
STATEMENT OF NEED
Venous thromboembolism (VTE) is a common and potentially life-threatening complication in patients with cancer. There are two main types of VTE: deep vein thrombosis (DVT) and pulmonary embolus (PE), which can cause right heart failure, cardiopulmonary collapse, and death (Ozaki & Bartholomew, 2012). Patients who develop PE require hospitalization, increased oxygen requireme...
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Management of Venous Thromboembolism in Hospitalized Patients With Cancer
STATEMENT OF NEED
Venous thromboembolism (VTE), which consists primarily of deep vein thrombosis (DVT) and pulmonary embolism (PE), is a life-threatening complication in hospitalized patients with cancer, and is associated with a 2- to 6-fold increase in likelihood of death (NCCN, 2016). The mainstay of treatment is anticoagulation; however, since cancer patients with VTE have higher rates of...
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Nursing Management of Bone Health in Patients With Cancer
STATEMENT OF NEED
Many tumors, such as prostate, breast, lung, and multiple myeloma, affect bone health. Once cancer spreads to the skeletal system, the risk for pain, fractures, hypercalcemia, and nerve compression increases considerably. Several studies have shown that the use of antiresorptive agents such as bisphosphonates and monoclonal antibodies can reduce the morbidity of skeletal com...
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Nursing Management of Cancer Treatment-Induced Cardiotoxicity
STATEMENT OF NEED
Several studies reveal that certain cancer therapies adversely affect the heart and lead to various types of injuries, which often result in death. Adverse cardiac effects may occur immediately after cessation of therapy or, in some cases, years after the therapy has been discontinued. Often the cardiotoxicity presents in subtle ways, and a lack of awareness results in high ...
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Nursing Strategies to Optimize Treatment Experiences in Hormone-Receptor Positive, HER2-Negative Metastatic Breast Cancer
STATEMENT OF NEED
Breast cancer accounts for nearly 30% of cancer diagnoses among women in the United States, and is the second-leading cause of cancer death in this population. Although many women benefit from regular screening as well as earlier and improved treatment, approximately 10% present with metastatic disease, and 30% with no initial lymph node involvement eventually develop metast...
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Optimizing the Management of Advanced Cervical Cancer With Checkpoint Inhibitor Therapy
STATEMENT OF NEED
There are an estimated 13,240 new cases of cervical cancer in the United States each year, and 4,170 people die of the disease. Due to screening and heightened awareness, deaths have declined during the past few decades. However, the malignancy continues to be a global health concern and is considered an epidemic in parts of the world. A significant proportion of patients de...
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Optimizing Treatment Experiences in Castration-Resistant Prostate Cancer
STATEMENT OF NEED
Prostate cancer is the most common tumor type in men in the United States. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be ...
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Understanding and Optimizing CAR T-Cell Therapy for Patients With B-Cell Malignancies
STATEMENT OF NEED
Although the clinical outcomes of patients with B-cell malignancies such as diffuse large B-cell lymphoma and B-cell acute lymphoblastic leukemia have improved during the past decade, many continue to develop relapsed or refractory disease, representing a significant cause of morbidity and mortality. CAR T-cell therapy has been shown to produce significant antitumor response...
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