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The Oncologist:Hyperammonemic Encephalopathy Associated With Fibrolamellar Hepatocellular Carcinoma: Case Report, Literature Review, and Proposed Treatment Algorithm

Learning Objectives: 1. Identify paraneoplastic hyperammonemic encephalopathy associated with fibrolamellar hepatocellular carcinoma. 2. Recognize cancer associated hyperammonemic encephalopathy and describe its pathophysiology. 3. Describe treatment algorithm of cancer-associated hyperammonemic encephalopathy. We report a case of a 31-year-old man with metastatic fibrolamellar hepatocellular carcinoma (FLHCC) treated with gemcitabine and oxaliplatin complicated by hyperammonemic encepha...
Society For Translational Oncology

Taking Action Against Chronic Hepatitis B Virus Infection: Counseling Patients on Serological Results

Hepatitis B virus (HBV) infection is a largely undetected and untreated disease in the United States. Only 33% of the estimated one million Americans living with HBV are aware that they are infected, placing them at risk for spreading the infection to others, and developing liver failure, cirrhosis, or hepatocellular carcinoma (HCC). As a result, HBV infection is the most common reason for liver transplantation. Primary care providers are not adequately screening at-risk patients for HBV in...
CME Outfitters, LLC

Taking Action Against Chronic Hepatitis B Virus Infection: Determining Which Patients to Treat or Monitor

Hepatitis B virus (HBV) infection is a largely undetected and untreated disease in the United States. Only 33% of the estimated one million Americans living with HBV are aware that they are infected, placing them at risk for spreading the infection to others, and developing liver failure, cirrhosis, or hepatocellular carcinoma (HCC). As a result, HBV infection is the most common reason for liver transplantation. Primary care providers are not adequately screening at-risk patients for HBV in...
CME Outfitters, LLC

Problem Based Learning in HBV: A Patient Simulation for Improving Treatment Decisions and Long-Term Care

Hepatitis B virus (HBV) infection is a largely undetected and untreated disease in the United States despite the availability of screening guidelines and prophylactic vaccines. Chronic HBV infection causes severe complications, including cirrhosis and hepatocellular carcinoma in 20% - 30% of patients. As a result, HBV infection is the most common reason for liver transplantation. While recommendations exist, primary care providers are not adequately screening at-risk patients for HBV infect...
CME Outfitters, LLC

Selecting Optimal Antiangiogenic Strategies for Patients With Hepatocellular Carcinoma

STATEMENT OF NEED Hepatocellular carcinoma is the sixth most common tumor globally, with an increasing incidence in the United States and Europe. The malignancy is the third leading cause of cancer-related death worldwide and the leading cause of death in patients with cirrhosis. Approximately 40,710 new cases are diagnosed in the United States annually and 28,920 people die of the disease. Patients with HCC continue to have a dismal prognosis, with a 5-year survival rate of 18%. This is du...
Postgraduate Institute for Medicine and i3 Health

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