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i3 Health

Understanding and Optimizing CAR T-Cell Therapy for Patients With B-Cell Malignancies

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Overview / Abstract:


Although the clinical outcomes of patients with B-cell malignancies such as diffuse large B-cell lymphoma and B-cell acute lymphoblastic leukemia have improved during the past decade, many continue to develop relapsed or refractory disease, representing a significant cause of morbidity and mortality. CAR T-cell therapy has been shown to produce significant antitumor responses in these patients, for whom treatment options are limited. However, CAR T-cell therapy is associated with serious adverse events such as cytokine release syndrome (CRS), neurotoxicity, anaphylaxis, B-cell aplasia, and tumor lysis syndrome. In addition, the development of resistance to CAR T-cell therapy represents a significant clinical challenge.


Oncology nurses, nurse practitioners, clinical nurse specialists, and other health care professionals involved in the treatment of patients with B-cell malignancies.


Upon completion of this activity, participants should be able to:

1. Describe the T-cell manufacturing workflow
2. Differentiate emerging efficacy and safety data on CAR T-cell therapy for relapsed/refractory B-cell malignancies
3. Apply strategies to manage adverse events associated with CAR T-cell therapy, including cytokine release syndrome and neurotoxicity


Feb 20, 2020


Nurse Practitioner , Nursing CNE


Monograph, Online

Credits / Hours




Presenters / Authors / Faculty

Stephanie Jackson, MSN, RN, AOCNS®, BMTCN® (Chairperson)
Oncology Clinical Nurse Specialist
Ronald Reagan UCLA Medical Center

Leslie Smith, RN, APRN-CNS, AOCNS®
Oncology and Transplant Clinical Nurse Specialist
National Institutes of Health Clinical Center

Sponsors / Supporters / Grant Providers

This activity is supported by an independent educational grant from Gilead.

Keywords / Search Terms

i3 Health i3 Health, CAR T, CAR T-cell, oncology, hematology, hematology/oncology, supportive care, B-cell malignancies, acute lymphoblastic leukemia, non-Hodgkin lymphoma, cytokine release syndrome, neurotoxicity, CE, free CE Free CE CME

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