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Integritas Communications

Managing Opioid-Induced Constipation: Translating Guidelines Into Patient Care

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Overview / Abstract:

Constipation, the most common side effect of chronic opioid therapy, is a constellation of symptoms that includes infrequent or incomplete bowel movements, abdominal pain or bloating, and the need to strain when having a bowel movement.1,2 In addition to constipation-related discomfort, opioid-induced constipation (OIC) produces significant health and quality-of-life burdens.3,4 Poorly managed OIC can lead patients to reduce or skip opioid doses, thereby decreasing adherence, increasing pain-related biopsychosocial complications, diminishing functional gains, and compromising overall outcomes.4-6

During this online Interactive Professorâ„¢ program, the expert faculty will present practical approaches to multimodal management of OIC. Presenting faculty will discuss initiation and escalation of appropriate therapies, including pharmacologic treatment modalities that have been specifically approved for OIC by the US Food and Drug Administration (FDA).7,8 This program will review the most recent evidence-based guidelines for management of OIC,9 as well as effective patient communication strategies for discussing opioid-related bowel issues and available treatment options. Participants will gain experience in a hands-on approach to bowel assessment, management strategies, and implementation of individualized treatment plans for patients with OIC.

Coyne KS, LoCasale RJ, Datto CJ, Sexton CC, Yeomans K, Tack J. Opioid-induced constipation in patients with chronic noncancer pain in the USA, Canada, Germany, and the UK: descriptive analysis of baseline patient-reported outcomes and retrospective chart review. Clinicoecon Outcomes Res. 2014;6:269-281.
Camillieri M, Drossman DA, Becker G, Webster LR, Davies AN, Mawe GM. Emerging treatments in neurogastroenterology: a multidisciplinary working group consensus statement on opioid-induced constipation. Neurogastroenterol Motil. 2014;26(10):1386-1395.
LoCasale RJ, Datto C, Wilson H, Yeomans K, Coyne KS. The burden of opioid-induced constipation: discordance between patient and health care provider reports. J Manag Care Spec Pharm. 2016;22(3):236-245.
Andresen V, Banerji V, Hall G, Lass A, Emmanuel AV. The patient burden of opioid-induced constipation: new insights from a large, multinational survey in five European countries. United European Gastroenterol J. 2018;6(8):1254-1266.
Harris JD. Management of expected and unexpected opioid-related side effects. Clin J Pain. 2008;24(suppl 10):S8-S13.
Gupta SH, Patel H, Scopel J, Mody RR. Impact of constipation on opioid therapy management among long-term opioid users, based on a patient survey. J Opioid Manag. 2015;11(4):325-338.
Chey WD, Webster L, Sostek M, Lappalainen J, Barker PN, Tack J. Naloxegol for opioid-induced constipation in patients with noncancer pain. N Engl J Med. 2014;370(25):2387-2396.
Argoff CE, Brennan MJ, Camilleri M, et al. Consensus recommendations on initiating prescription therapies for opioid-induced constipation. Pain Med. 2015;16(12):2324-2337.
Crockett SD, Greer KB, Heidelbaugh JJ, Falck-Ytter Y, Hanson BJ, Sultan S; American Gastroenterological Association Institute Clinical Guidelines Committee. American Gastroenterological Association Institute guideline on the medical management of opioid-induced constipation. Gastroenterology. 2019;156(1):218-226.


Jan 03, 2021


Clinical Laboratory CE, Nurse Practitioner , Nursing CNE, Physician CME, Physician Assistant CME


Webinar / Webcast / Video

Credits / Hours




Presenters / Authors / Faculty

Jeffrey A. Gudin, MD

Activity Specialities / Related Topics

Gastroenterology / GI, Oncology / Cancer / Radiation Therapy, Pain Management

Sponsors / Supporters / Grant Providers

This activity is supported by an educational grant from AstraZeneca.

Keywords / Search Terms

Integritas Communications Opioid induced constipation, constipation, pain, management, cancer, oncology, nursing credit, moc credit, cme, ce, credit Free CE CME

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