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Integritas Communications

JAKi in RA Practice: Unpacking the Evidence for Their Use Today and Tomorrow

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Overview / Abstract:

The Janus kinase (JAK) family of intracellular tyrosine kinases plays a pivotal role in transducing extracellular cytokine signaling, thereby contributing to major processes such as cellular proliferation, homeostasis, and host defense against infection.1 In RA, certain JAK-mediated signaling pathways are dysfunctionally active, leading to enhanced transcription of various proinflammatory genes and aberrant immune responses.2 In this Interactive Exchangeâ„¢ activity, a panel of expert rheumatologists will discuss the rationale underscoring targeted JAK inhibition, the latest clinical evidence on available and emerging JAK inhibitor therapies, evolving RA treatment guidelines, and challenges surrounding the appropriate and timely use of JAK inhibitors. The overall goal of this activity is to assist participates in translating the latest information regarding JAK inhibitor therapy into improved RA management and patient care.

1. Winthrop KL. The emerging safety profile of JAK inhibitors in rheumatic disease. Nat Rev Rheumatol. 2017;13:234-243.
2. Malemud C. The role of the JAK/STAT signal pathway in rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2018;10:117-127.


Feb 25, 2021


Nurse Practitioner , Nursing CNE, Physical Therapy CE, Physician CME, Physician Assistant CME


Webinar / Webcast / Video

Credits / Hours




Presenters / Authors / Faculty

Kenneth Kalunian, MD, FACR (Chair); Maria Greenwald, MD, FACR; John Isaacs, MBBS, PhD, FRCP

Activity Specialities / Related Topics

Rheumatology / Arthritis

Sponsors / Supporters / Grant Providers

This activity is supported by an educational grant from Gilead Sciences, Inc., and is jointly provided by Global Education Group and Integritas Communications.

Keywords / Search Terms

Integritas Communications Integritas Communications, Rheumatoid Arthritis, RA, CME, CE, Continuing Medical Education, Continuing Education, Free CE, Free CME, video, webcast, JAKi, JAK Inhibitors, Kalunian, Greenwald, Isaacs, Global Education Group, Janus kinase, clinical rheumatologists, specialist nurse practitioners, physician assistants, signal transducers and activators of transcription, STAT, ACCME Free CE CME

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