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CME Outfitters

The Complete Response: Addressing Antidepressant Failure in Patients with Major Depressive Disorder

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Overview / Abstract:

Major depressive disorder (MDD) is a profoundly debilitating, lifelong disorder. Many patients do not achieve remission with initial first-line antidepressant therapy, which is typically comprised of selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs). Subsequently, patients endure a high burden of treatment failure, though it is often unrecognized. Measurement-based care (MBC) is a proven strategy for monitoring treatment effectiveness and signaling clinicians when alternative strategies are warranted, yet MBC is not routinely implemented into practice.

This CME Outfitters webcast will provide family medicine clinicians with real-world strategies to incorporate MBC into routine practice to rapidly detect suboptimal treatment outcomes. In addition, faculty experts will guide family medicine clinicians through developing safe and effective alternative antidepressant therapy with unique MOAs when patients experience treatment failures with initial SSRIs/SNRIs.

Learning Objectives
At the end of this CME/CE activity, participants should be able to:

- Incorporate MBC into primary care settings to identify suboptimal treatment responses with initial antidepressant therapy for MDD that can impede remission and functional recovery.
- Evaluate the impact of antidepressants with unique mechanisms of action (MOAs) on safety, efficacy, and tolerability relative to traditional antidepressants.
- Apply best practices for switching to antidepressants with a different MOA when initial response to SSRI/SNRI treatment results in residual symptoms, inadequate response, or intolerable side effects.


Sep 29, 2022


Nurse Practitioner , Nursing CNE, Pharmacy CPE, Physician CME, Physician Assistant CME, Psychology CE


Online, Webinar / Webcast / Video

Credits / Hours

1.5 AMA PRA Category 1 Credit(s)™, 1.5 CEUs, 1.5 contact hours



Presenters / Authors / Faculty

Michael E. Thase, MD
Professor of Psychiatry
Department of Psychiatry
Perelman School of Medicine at the University of Pennsylvania
Corporal Michael J. Crescenz Veterans Affairs Medical Center
Philadelphia, PA

W. Clay Jackson, MD, DIpTh
Clinical Assistant Professor
Family Medicine and Psychiatry
University of Tennessee College of Medicine
Memphis, TN

Karen Hyden, PhD, APN-BC, MSN/Ed, ACHPN
Area Vice President of Palliative Care, Amedisys, Inc.
Nashville, TN

Sponsors / Supporters / Grant Providers

Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc. and Lundbeck.

Keywords / Search Terms

CME Outfitters depression, psychiatry, neurology, neuroscience, MDD, mental health, mental illness, psychiatric, psych, anxiety, bipolar, antidepressant, free CME, free CE, free webcast, family medicine Free CE CME

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