Overview / Abstract: |
STATEMENT OF NEED Breast cancer is the most commonly diagnosed cancer in women. A BRCA1 or BRCA2 mutation is found in approximately 5% of patients with breast cancer and is detected in 30% of patients who have a family history of breast or ovarian cancer (ACS, 2019). In patients with human epidermal growth factor receptor 2 (HER2)"negative breast cancer with deleterious or suspected deleterious germline BRCA mutations, inhibition of poly"(ADP-ribose) polymerase (PARP) is highly efficacious, even in early breast cancer. PARP inhibitors block pathways involved in DNA single-stranded break repair. In combination with a germline or somatic mutation impacting the homologous recombination DNA repair genes BRCA1 or BRCA2, PARP inhibition leads to stalled replication, DNA damage, and cancer cell death (Cortesi et al, 2021). In this session, Janie Metsker, RN, BSN, CN-BN, will explain the benefit of PARP inhibitors for breast cancer in patients with germline BRCA mutations and will present the latest data justifying the recent approval of olaparib for adjuvant therapy in high-risk early breast cancer (Tutt et al, 2021). She will also highlight the side effect profiles of PARP inhibitors and the importance of counseling patients about the side effects they may experience. TARGET AUDIENCE Oncology nurses, nurse practitioners, physician assistants, pharmacists, oncologists, and other health care professionals involved in the treatment of patients with breast cancer. LEARNING OBJECTIVES Upon completion of this activity, participants should be able to |
Expiration |
Dec 06, 2023 |
Discipline(s) |
Nurse Practitioner , Nursing CNE, Physician CME, Physician Assistant CME |
Format |
Online |
Credits / Hours |
1.0 CME | 1.0 NCPD | CPE | MOC | ILNA |
Accreditation |
ACCME, ANCC |
Presenters / Authors / Faculty |
Janie Metsker, RN, BSN, CN-BN |
Sponsors / Supporters / Grant Providers |
This activity is supported by independent educational grants from Gilead Sciences, Inc. and Puma Biotechnology. |
Keywords / Search Terms |
Oncology, i3 Health, CME, NCPD, free CNE, free NCPD, Free CE, Free CME, Nursing, Oncology Nursing, Breast Cancer, Breast Cancer Therapies, Physician, Oncology Physician, PARP Inhibitors |