The Promise of Nerve Growth Factor Therapy: Managing Neurotrophic Keratitis and Beyond

The early diagnosis and management of neurotrophic keratitis (NK) is imperative to avoid complications such as ulceration, infection, stromal melting, perforation secondary to poor healing, and vision loss. Diagnosis of the early stages of NK can be challenging because patients typically experience few symptoms, which leads to delays in management initiation and the potential for epithelial damage. Current and emerging treatment options―when integrated optimally into management protocols―restore corneal sensitivity and promote healing of the ocular surface, thus halting disease progression. Increasing evidence has demonstrated that nerve growth factor (NGF) plays an important role in corneal pathophysiology; this emerging data supports not only its utilization in the management of NK, but also its potential use in the management of other ocular conditions and diseases. In this continuing medical education activity, experts in the field examine the role of endogenous NGF in ocular surface homeostasis, assess the efficacy and safety of recombinant NGF therapy in the treatment of neurotrophic keratitis, and discuss potential applications of NGF therapy in various ocular conditions and diseases.