A Breath of Fresh Air: Novel Treatments That Address the Inflammatory Component of Non-Cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis (NCFBE) is a heterogenous and increasingly prevalent chronic pulmonary disease that is associated with high morbidity and mortality. It is characterized by irreversibly damaged and dilated bronchi, and has a broad spectrum of clinical presentations, ranging from asymptomatic radiological changes detected incidentally to chronic sputum production and recurrent e...
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A Class Act in Glaucoma Management: Differentiating Rho Kinase Inhibitors From the Pack
Medical management of glaucoma primarily focuses on lowering intraocular pressure (IOP) by decreasing aqueous production, reducing episcleral venous pressure, and/or increasing uveoscleral and trabecular outflow. Recently approved agents have expanded treatment options beyond the traditional mainstays of prostaglandin analogues and β-blockers, engaging Rho kinase (ROCK) inhibition to improve ou...
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Ace the Case: A 34-Year-Old Woman With Painful Swallowing
This educational activity will utilize a case study to discuss a 34-year-old woman with painful swallowing that has been progressively worsening for the past few days and is associated with anorexia, nausea, and epigastric abdominal pain.
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Ace the Case: A 47-Year-Old Man With Oral Corticosteroid-Dependent Asthma
This educational activity will utilize a case study to discuss a 47-year-old man with oral corticosteroid"dependent asthma.
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Ace the Case: A 62-Year-Old Woman With Unintentional Weight Loss of 20 Pounds
This educational activity will utilize a case study to discuss a 62-year-old woman with a 20-pound unintentional weight loss and recurrent emesis over the past 3 months.
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Ace the Case: A 65-Year-Old Woman With Chronic Diabetic Macular Edema in Both Eyes
In this clinical case review, Dr. Sara Haug explores considerations for the management of a patient with DME who is receiving monthly anti-VEGF therapy without attaining disease control.
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Ace the Case: A 76-Year-Old Male With Active Neovascular Age-Related Macular Degeneration
In this clinical case review, Dr. Arshad Khanani explores options for switching treatment in a patient with nAMD who has become nonresponsive to anti-vascular endothelial growth factor (VEGF) therapy.
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Ace the Case: An 84-Year-Old Man With Neovascular Age-Related Macular Degeneration Receiving Bilateral Every 8-Week Anti-Vascular Endothelial Growth Factor Injections
In this clinical case review, Dr. Emmanuel Chang explores options to extend treatment intervals in a patient with stable nAMD who is receiving anti-VEGF therapy every 8 weeks.
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Best of Lipid Forum®: Examining the Role of Lp(a) as a Risk Factor in Atherosclerotic Cardiovascular Disease
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein particle that is associated with poor cardiovascular prognosis due to its pro-atherogenic, pro-thrombotic, pro-inflammatory and pro-oxidative properties. Unfortunately, traditional lipid-lowering therapy does not provide sufficient Lp(a) reduction. High levels of Lp(a) are an independent and causal risk factor for atherosclerotic cardiovascular...
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Best of Lipid Forum®: Examining the Role of Lp(a) as a Risk Factor in Atherosclerotic Cardiovascular Disease
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein particle that is associated with poor cardiovascular prognosis due to its pro-atherogenic, pro-thrombotic, pro-inflammatory and pro-oxidative properties. Unfortunately, traditional lipid-lowering therapy does not provide sufficient Lp(a) reduction. High levels of Lp(a) are an independent and causal risk factor for atherosclerotic cardiovascular...
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Case Challenges in nAMD and DME Management: Achieving Durable Response
The management of diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD) with intravitreal anti-vascular endothelial growth factor (VEGF) therapies has provided enhanced visual outcomes for many patients. However, the high treatment burden associated with anti-VEGF therapies can lead to lack of patient adherence, resulting in suboptimal outcomes. Personalized treatm...
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Clinical Evidence for COVID PrEP, With Drs. Leonard Calabrese and Myron Cohen
In this podcast, expert clinicians will review recent developments involving monoclonal antibody therapies for COVID-19 and discuss ongoing studies on pre-exposure prophylaxis for immunocompromised patients.
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COVID-19 Disease Behavior in Immunocompromised Patients, With Drs. Leonard Calabrese and Alfred Kim
In this podcast, expert clinicians will discuss how immune compromising conditions and iatrogenic causes of immune suppression affect risk for infection and severe outcomes with COVID-19.
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Diabetic Macular Edema: Employing Inflammatory Markers to Predict Improved Visual Outcomes
Real-world outcomes with intravitreal anti-vascular endothelial growth factor (VEGF) therapy in the treatment of patients with diabetic macular edema (DME) do not always replicate those seen in clinical studies. In part, these discrepancies are due to treatment burden, lack of adherence, undertreatment, and incomplete response to anti-VEGF therapies. The identification of several inflammatory cy...
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Diabetic Macular Edema: Employing Inflammatory Markers to Predict Improved Visual Outcomes
Real-world outcomes with intravitreal anti-vascular endothelial growth factor (VEGF) therapy in the treatment of patients with diabetic macular edema (DME) do not always replicate those seen in clinical studies. In part, these discrepancies are due to treatment burden, lack of adherence, undertreatment, and incomplete response to anti-VEGF therapies. The identification of several inflammatory cy...
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EGPA Expert Exchange " A Podcast Series on Eosinophilic Granulomatosis With Polyangiitis
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is a rare form of vasculitis that primarily affects the small blood vessels. Individuals diagnosed with EGPA commonly have a history of asthma and/or allergies. Eosinophilic inflammation associated with EGPA can lead to injury in multiple organ systems, including the sinuses, lungs, gastrointestinal sys...
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Eosinophilic Esophagitis: Experts Address Your Burning Questions
Eosinophilic esophagitis (EoE) is a chronic type 2 helper (Th2)-mediated inflammatory disorder that is characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. Once considered rare, EoE is a relatively new disease that is now commonplace and affects both children and adults. When left unmanaged, EoE can impact a patient’s ability to eat ...
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Eyeing the Options for Treating Meibomian Gland Dysfunction and Dry Eye Disease
Dry eye disease (DED) is highly prevalent but frequently underdiagnosed and subsequently undertreated. Studies have demonstrated that meibomian gland dysfunction (MGD) is a leading cause of the development and progression of evaporative DED, caused by a deficient tear film lipid layer that leads to increased tear evaporation. New and emerging treatments with novel mechanisms of action are being ...
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Geographic Atrophy: Rapid Response from ARVO
Geographic atrophy (GA) is a pathological deterioration of the retina seen in the late stages of age-related macular degeneration (AMD). It affects 20% of people with AMD, and its prevalence increases exponentially with age. Until recently, there were no treatment options for GA, but investigation into the complement system and its role in the pathogenesis of GA has led to targeted therapies tha...
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HIV Snippets " A Podcast Series: Optimizing Care in HIV Treatment and Prevention
Antiretroviral therapy (ART) for treating HIV has improved dramatically over the past decade. This progress has yielded more treatment choices for clinicians and patients but also adds greater complexity to the already-diverse field of HIV treatment. In this CE activity, participants will listen to expert faculty in a series of 4 podcasts. The faculty will explore various aspects of HIV manageme...
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In Case You Missed: Utilizing the Muscarinic System to Optimize Treatment Options for Schizophrenia
Schizophrenia is an incurable, neuropsychiatric disease characterized by difficulties thinking and communicating clearly as well as psychosis (ie, “positive” symptoms); difficulty functioning socially (ie, “negative” symptoms); and cognitive impairment. As many as 34% of patients with schizophrenia have treatment-resistant schizophrenia, defined as continuing symptoms despite at least 2 ...
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Major Depressive Disorder & Postpartum Depression: Targeting the GABA Deficit
Major depressive disorder (MDD), perinatal depression, and postpartum depression (PPD) are increasingly prevalent conditions that carry an extremely high disease burden. Underdiagnosis and undertreatment of major depressive episodes have led to significant unmet needs for these patient populations. Success of treatment with traditional antidepressants that target monoaminergic deficiencies and i...
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Managing Thyroid Eye Disease: Rapid Response From ENDO
For a timely diagnosis and optimal management of thyroid eye disease (TED), a multidisciplinary team of endocrinologists, ophthalmologists, oculoplastic surgeons, as well as other healthcare professionals is essential. Early diagnosis of TED through imaging and clinical assessment is imperative to allow for the timely initiation of therapeutic strategies that limit disfiguration and reduce the p...
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MedEd Talks: Case-Based Conversations in Rheumatology
Immune-mediated inflammatory disease (IMID) is a group of clinically heterogeneous autoimmune disorders that includes psoriatic arthritis, systemic lupus erythematosus, vasculitis, and many others. Recognizing the underlying immunopathologic mechanisms of these disorders is essential for understanding how new and emerging biologic and small molecule therapies exert their effects, enabling optima...
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Meeting Milestones in nAMD and DME Management: What's New?
Anti-vascular endothelial growth factor (VEGF) therapy has revolutionized treatment paradigms for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). However, these agents are associated with a high treatment burden because of the injection frequency, and a substantial number of patients do not adhere to their treatment schedules, resulting in suboptimal respons...
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nAMD and DME Management: Rapid Response From ARVO
Real-world outcomes with anti-vascular endothelial growth factor (VEGF) therapies in the management of patients with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) are often not comparable to those of clinical studies. Discrepancies in these outcomes have been associated with undertreatment due to high treatment burden and the associated loss of patient adher...
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nAMD and DME Management: Rapid Response From ARVO
Real-world outcomes with anti-vascular endothelial growth factor (VEGF) therapies in the management of patients with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) are often not comparable to those of clinical studies. Discrepancies in these outcomes have been associated with undertreatment due to high treatment burden and the associated loss of patient adher...
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Neuromyelitis Optica Spectrum Disorder: Management Updates and Challenging Clinical Cases
Neuromyelitis optica spectrum disorder (NMOSD) is a rare, relapsing, autoimmune disease of the central nervous system that mainly manifests through recurrent attacks of optic neuritis and longitudinally extensive transverse myelitis. NMOSD is often misdiagnosed in the early stages, but the integration of newer diagnostic criteria may assist in an earlier and more accurate differential diagnosis....
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Neuromyelitis Optica Spectrum Disorder: Management Updates and Challenging Clinical Cases
Neuromyelitis optica spectrum disorder (NMOSD) is a rare, relapsing, autoimmune disease of the central nervous system that mainly manifests through recurrent attacks of optic neuritis and longitudinally extensive transverse myelitis. NMOSD is often misdiagnosed in the early stages, but the integration of newer diagnostic criteria may assist in an earlier and more accurate differential diagnosis....
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Neuromyelitis Optica Spectrum Disorder: Optimizing Clinical Decision-Making in a Rapidly Evolving Therapeutic Landscape
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the central nervous system that mainly manifests through recurrent attacks of optic neuritis and longitudinally extensive transverse myelitis. Although early detection is critical for improved outcomes, misdiagnosis is common during the early stages of disease. The application of newer diagnostic criteria and methods ...
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Neuromyelitis Optica Spectrum Disorder: Updates on Diagnosis and Treatment Management
Neuromyelitis optica spectrum disorder (NMOSD) is a rare, relapsing, autoimmune disease of the central nervous system that is characterized by inflammation in the optic nerve and spinal cord. Unfortunately, early stages of NMOSD are frequently misdiagnosed as multiple sclerosis or other diseases. Diagnosis is typically based on the presence of key clinical characteristics"aquaporin-4 (AQP4)...
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Outpatient Management of COVID-19 Immunocompromised Patients: Educating the Practitioner, With Drs. Leonard Calabrese and Myron Cohen
In this podcast, expert clinicians will discuss outpatient management of COVID-19 and strategies to educate practitioners on best practices for those caring for immunocompromised patients.
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Parkinson’s Disease " Updates in Diagnosis and Patient Management
Parkinson's disease is a neurodegenerative disorder, second only in prevalence to Alzheimer’s disease. Numerous therapeutic options, including carbidopa/levodopa, monoamine oxidase-B inhibitors, dopamine agonists, and device-assisted therapies, are available for treatment. These treatments are indicated at different stages following diagnosis. However, Parkinson’s disease progresses at ...
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Tracking and Treating Uveitic Macular Edema: A Difficult Dilemma
Uveitic macular edema (UME) has a wide variety of causes. If not appropriately treated, it eventually causes damage to the photoreceptors in the macula, resulting in vision-threatening complications like macular ischemia or macular hole formation. Corticosteroids are the first-line treatment for uveitic inflammation and UME. However, they are not generally considered to be appropriate for long-t...
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Tracking and Treating Uveitic Macular Edema: A Difficult Dilemma
Uveitic macular edema (UME) has a wide variety of causes. If not appropriately treated, it eventually causes damage to the photoreceptors in the macula, resulting in vision-threatening complications like macular ischemia or macular hole formation. Corticosteroids are the first-line treatment for uveitic inflammation and UME. However, they are not generally considered to be appropriate for long-t...
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Ulcerative Colitis and the Role of S1P Receptor Modulators and JAK Inhibitors " A Wheel of Knowledge Challenge!
Ulcerative colitis (UC), a type of inflammatory bowel disease, is a chronic relapsing condition characterized by an overly active immune response in the large intestine, resulting in inflammation and ulceration. Given the increasing prevalence of disease and rapid influx of available biologics and small molecule therapies, there is great need for ongoing education regarding new and emerging trea...
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