Eosinophilic Esophagitis: Novel Therapeutic Developments and Impact on Treatment Paradigms

Eosinophilic esophagitis (EoE) is a chronic, type-2 helper (Th2)-mediated inflammatory disorder that affects both children and adults. It is characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. Once considered rare, EoE is a relatively new disease that is now commonplace. When left unmanaged, EoE can impact a patient’s ability to eat properly, leading to food impaction and increased medical expenses. Real-world data indicate that many patients with EoE switch therapy frequently, demonstrating an unmet need for adequate control of disease-related symptoms. Many gastroenterologists and other relevant health care providers lack an understanding of the pathogenesis, guideline-based diagnostic criteria, and newly approved and emerging treatment options for EoE. These knowledge deficits may therefore exacerbate delays in diagnoses and, consequently, appropriate management. In this educational program, expert clinicians review the pathogenesis and best practices for the accurate diagnosis of EoE. They also explore current treatment guidelines and the clinical data supporting the use of recently approved and emerging therapies for EoE. Interactive case discussions are included to challenge the audience’s ability to apply the learnings from the didactic presentations.