Leveraging BCMA-Directed Therapies for Improved Patient Outcomes in Relapsed/Refractory Multiple Myeloma
STATEMENT OF NEED
Multiple myeloma is a disease that remains incurable for most patients, many of whom become refractory to the majority of available treatments (Kumar et al, 2022). It is estimated that 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Agents targeting B-cell maturation antigen (BCMA), including antibody-drug conjugates (ADCs), chimeric antigen receptor (CAR) T-cell therapies, and bis... |
|
Warm Autoimmune Hemolytic Anemia (wAIHA)
Warm autoimmune hemolytic anemia (wAIHA) is the most common type (60-70%) of autoimmune hemolytic anemia (AIHA). In most cases, wAIHA is due an immunoglobulin G (IgG) autoantibody that binds to red blood cells (RBC), leading to hemolysis.
Current recommendations for managing people with wAIHA are largely based on case series and retrospective studies involving off-label medications. Also, while there are currently no medications specifically approved to treat wAIHA, data are emerging on new... |
|
Expert Guidance on Current Standards and New Directions in Newly Diagnosed Multiple Myeloma
STATEMENT OF NEED
An estimated 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Characterized by clonal proliferation of malignant plasma cells in the bone marrow, multiple myeloma is associated with anemia, renal insufficiency, bone destruction, and hypercalcemia, all of which significantly impact patients’ quality of life. The development of novel therapies and combinations in recent years, inclu... |
|
Leveraging the Growing Arsenal of Adjuvant Therapies for Early-Stage NSCLC
In this activity, Dr. Helena A. Yu, Associate Attending Physician at Memorial Sloan Kettering Cancer Center, will provide insights into strategies for leveraging the growing arsenal of adjuvant therapies for early-stage non"small cell lung cancer (NSCLC), including treatment selection and adverse event management. Start the activity now!
STATEMENT OF NEED
Lung cancer is the second most commonly diagnosed cancer and the leading cause of death for men and women worldwide. In the Unite... |
|
Managing Immune Related Adverse Events to Ensure Optimal Cancer Immunotherapy Outcomes: The Nurse’s View
STATEMENT OF NEED
Immune checkpoint inhibitors, which alter immune regulatory pathways and promote cell-mediated destruction of tumor cells, have revolutionized the treatment of cancer in recent years, with numerous therapeutic agents approved and several targets under investigation (Chennamadhavuni et al, 2022). However, up to 90% of patients receiving immune checkpoint inhibitors experience immune-related adverse events, which can affect a wide variety of organ systems and can occur at any ... |
|
Recurrent and Metastatic HNSCC: New Insights and Real-World Evidence for Improved Patient Outcomes
STATEMENT OF NEED
Head and neck cancers represent a heterogeneous group of tumors that originate in the lip/oral cavity, hypopharynx, oropharynx, nasopharynx, and larynx. An estimated 66,470 new cases are diagnosed in the United States annually, and 15,050 people die of the disease (Siegel et al, 2022). Approximately 90% of cases are classified as head and neck squamous cell carcinoma (HNSCC). Treatment of HNSCC is complicated by numerous factors, including differing therapeutic strategies ... |
|
|
Real-World Perspectives in Managing CLL Treatment
Management options for chronic lymphocytic leukemia (CLL) have expanded in recent years. The emergence of new immunotherapeutic and targeted agents for both the first-line and relapsed/refractory settings"though of course beneficial for CLL patients"represents a challenge to clinicians, who must navigate the indicated uses, mechanisms of action, and toxicity profiles of these new agents. In determining optimal treatment plans, clinicians are also confronted with significant advances ... |
|
The Role of the Clinical Pharmacist in the Management of Multiple Myeloma
Multiple myeloma (MM) is the second most common hematologic malignancy in the United States and is characterized by monoclonal proliferation of malignant plasma cells that accumulate within the bone marrow. The incidence of MM has increased in recent years, in part due to the revised definition of symptomatic MM from the International Myeloma Working Group in 2014. The National Cancer Institute estimated a total of 34,470 new cases in 2022, with 12,640 deaths. Despite significant advancements ... |
|
Combining Locoregional and Systemic Therapy for Challenging HCC Cases
Target Audience
This educational activity is intended for interventional oncologyists physicians, nurses, and other members of the health care team who care for patients with hepatocellular carcinoma (HCC)
Program Overview
This activity focuses on challenges in the management of HCC using the latest clinical data supporting locoregional therapy, and on strategies for greater collaboration amongst the multidisciplinary teams in community vs academic settings.
Learning Objectives
Upon c... |
|
Warm Autoimmune Hemolytic Anemia (wAIHA)
Target Audience
This activity has been designed to meet the educational needs of physicians specializing in hematology and hematology-oncology. Other members of the care team may also participate.
Program Overview
Warm autoimmune hemolytic anemia (wAIHA) is the most common type (60-70%) of autoimmune hemolytic anemia (AIHA). In most cases, wAIHA is due an immunoglobulin G (IgG) autoantibody that binds to red blood cells (RBC), leading to hemolysis.
Current recommendations for managing ... |
|
Optimizing Transition from Pediatric to Adult Care - LIVE STREAMING
In this special program, faculty from Harvard Medical School, the Brigham Transition Care Team, and the Boston Children’s Hospital BRIDGES Adult Transition Program provide strategies, best practices, and guidance to:
• Identify adult care providers and successfully transfer patients with rare or complex health care needs
• Assess and improve the efficacy of your current transition processes
• Tailor transition strategies to patient age, disease type, and physical/ intellectual capab... |
|
NeuroRehabilitation 2024 - LIVE STREAMING
Comprehensive Neurorehabilitation Update
Cutting-edge strategies, updates, and best practices for state-of-the-art rehabilitation
In this course, which is among the highest-rated Harvard Medical School CME courses, many of the country’s most experienced and committed neurorehabilitation experts will present cutting-edge clinical interventions, the latest findings, practical education, and hands-on methods to further your expertise in guiding your patients with stroke, SCI, TBI, brain t... |
|
Is It Safe? Safety Surveillance through the Antiretroviral Pregnancy Registry
Is It Safe? Safety Surveillance through the Antiretroviral Pregnancy Registry
Release Date: June 2, 2023
Expiration Date: June 2, 2024
Estimated Time to Complete: 1.25 hour
VIEW ACTIVITY
Clinical Gap and Educational Need
Antiretroviral therapy should be initiated for all persons with HIV who are pregnant regardless of CD4 count according to current guidelines. There is often minimal data available to make recommendations, however, for use in pregnancy. One key consideration is... |
|
Graft vs Host Disease: Novel Management Strategies for a Chronic Condition
Target Audience
The intended audience for this activity is transplant specialists, oncologists, hematologists, and other healthcare professionals involved in the treatment of patients with GVHD.
Program Overview
This enduring activity takes learners on a compelling journey in managing chronic graft-versus-host disease (cGVHD) by explaining the evidence-based diagnostic criteria for cGVHD for prompt diagnosis; discussing the clinical safety and efficacy data of recently approved and invest... |
|
Diagnosis and Management of Patients With Predominant Skin Symptoms
The educational design of this activity addresses the needs of allergy/clinical immunology, gastroenterology, dermatology, and hematology clinicians who manage patients with nonadvanced systemic mastocytosis.
Nonadvanced systemic mastocytosis (SM) is a group of rare disorders characterized by mast cell accumulation that results in a significant and varied symptomatic burden to the patient. The most prevalent of these symptoms include gastrointestinal symptoms, dermatological symptoms, and ... |
|
Navigating the Evolving Treatment Landscape of Renal Cell Carcinoma to Ensure Equitable Access to Quality Care
Target Audience
This activity is designed specifically for oncologists, advanced practice providers, and other members of the healthcare team who serve patients from rural and underserved communities.
Program Overview
Therapeutic options for metastatic renal cell carcinoma (RCC) have expanded over the last decade and now include targeted therapies as well as immunotherapies. However, workforce shortages, low rates of recruitment into clinical trials, racial and socioeconomic inequities, a... |
|
Making the Call in Nonadvanced Systemic Mastocytosis Optimizing Multidisciplinary Management
Series Overview
Nonadvanced systemic mastocytosis (SM) is a group of rare disorders characterized by mast cell accumulation that results in a significant and varied symptomatic burden to the patient. The most prevalent of these symptoms include gastrointestinal symptoms, dermatological symptoms, and recurrent anaphylaxis in response to a variety of triggers such as food, insect venom, and medications. In this Phone-a-Friend series, a multidisciplinary panel of faculty experts will address the... |
|
Case Studies in Hereditary Angioedema: Moving Beyond Crisis to Long-Term Prevention
Hereditary angioedema (HAE) is an autosomal dominant condition that causes recurring, unpredictable, and potentially fatal attacks resulting in a profound disease burden and diminished health-related quality of life (QoL). Recent advances have led to new therapies for HAE, including long-acting prophylactic therapies that have improved efficacy, tolerability, and convenience, compared to earlier treatments. Many health care providers are unaware of HAE and its diagnosis, particularly the diffe... |
|
Fetal and Women's Imaging 2023- Advanced OB-GYN Ultrasound
World Class CME is again proud to host the annual Fetal and Women's Imaging conference in Seattle, Washington. We welcome everyone to The Marriott Seattle Waterfront for yet another excellent three day course in 2024.
“Welcome to Seattle and Fetal & Women’s Imaging: Advanced OB-GYN Ultrasound 2024. This year’s comprehensive program is designed with something for both novice and advanced learners. Our extensive gynecology program will update you with the latest guid... |
|
Dermatological Compounding
September 13th- 14th, 2024
DERMATOLOGICAL COMPOUNDING is an accredited 15 hour (1.5 CEUs) knowledge / application-based course that comprises a blend of didactic lectures for theoretical understanding and laboratory activities for practical application. This approach enhances an already established skill of compounding, providing you with a more in-depth insight into the field. However, it is recommended for participants to have a solid understanding of fundamental compounding techniques an... |
|
Crucial Conversations in Pharmacy Practice: Improving Patient Outcomes in Shingles Management
Shingles management"or more specifically, the prevention of shingles (caused by varicella zoster virus; VZV)"is crucial to help preserve quality of life, particularly for older adults. Updated immunization recommendations for recombinant zoster vaccine (RZV) now include updated guidance for adults with compromised immune systems in addition to older adults. Pharmacists play a key role in the interprofessional team with appropriate identification, recommendation, and administration ... |
|
LET'S TALK: Tackling Complex Issues Regarding SM-AHN Management A Monday Morning Joe Online Educational Activity
Systemic mastocytosis (SM) is a group of rare disorders characterized by the accumulation of mast cells in internal tissues and organs. The pathogenesis of SM is linked to a characteristic exon 17 D816V mutation of the KIT gene. Systemic mastocytosis with associated hematologic neoplasms (SM-AHN) is an advanced subtype of SM that is associated with a shortened median survival time. Recent advances in the SM therapeutic landscape have led to the development of KIT-targeted treatment options; ho... |
|
Nursing Management of Tumor Lysis Syndrome
STATEMENT OF NEED
Tumor lysis syndrome (TLS) is an oncological emergency that occurs when massive tumor lysis causes the rapid release of intracellular components into the bloodstream. Electrolyte imbalances characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia may be severe enough to cause acute renal failure, cardiac arrhythmias, seizures, and even death. Current advances in cancer therapies can increase the incidence of TLS; therefore, identification of patien... |
|
Treating Hepatitis C in Patients with HIV Disease
This course addresses the complexities of HIV disease in the era of improved survival: management of HIV co-infection.
Outcome Objectives:
As a result of completing this activity, the participant will be better able to:
- Diagnose the clinical syndrome of porphyria cutanea tarda.
- Diagnose hepatitis C.
- Adjust the treatment of hepatitis C based on viral genotype and liver pathology. |
|
The Immune Reconstitution Syndrome in AIDS
This course addresses the complexities of HIV disease in the era of improved survival: recognition and management of the immune reconstitution syndrome.
Outcome Objectives:
As a result of completing this activity, the participant will be better able to:
- Recognize that restoration of immunologic function in persons with HIV disease may lead to a worsening clinical picture, the immune reconstitution syndrome.
- Diagnose and manage occult opportunistic infections in persons with newly... |
|
Therapeutic Advancements for the Treatment of High-Risk MDS: Future Opportunities to Improve Patient Survival and Quality of Life
Stay up to date on the evolving risk classification for myelodysplastic syndromes (MDS) and current treatment guidelines for patients with high-risk disease in this self-directed education with leading oncology experts. Expert commentary from Courtney DiNardo, MD from MD Anderson Cancer Center and Dr. Dan Pollyea from the University of Colorado School of Medicine provides insights on emerging therapies that could soon improve management of high-risk MDS. Be ready to incorporate these emerging ... |
|
Individualized Strategies for Relapsed/Refractory Multiple Myeloma: Navigating Complexity with BCMA-Targeted and Novel Bispecific Antibodies
The expanding armamentarium of therapies for R/R MM shifts therapy selection from an algorithmic approach to an individualized strategy that requires consideration of the nature of relapse, prior therapies, treatment-related toxicities, as well as patient comorbidities and preferences. With the introduction of novel bispecific antibodies, specialists must learn how to optimally sequence these therapies and manage adverse events. To help clinicians navigate this complexity, individualized educa... |
|
Physical Assessment - A Certificate Training Workshop for Pharmacy Practitioners
As pharmacists expand their scope of practice under
new legislation (SB493), physical assessment is a key
skill necessary for advanced practice. This 21 hour
course will prepare the pharmacist to obtain a
history and perform a basic physical examination
that will enable them to assess and monitor drug
therapy. The course will employ written materials,
videos, lectures, demonstrations and hands on
practice and feedback
Objectives for Pharmacists
At the conclusion of the course the p... |
|
Addressing Key Questions About BCMA-Targeted Therapy for Relapsed/Refractory Multiple Myeloma
ACTIVITY DESCRIPTION
Though treatment advances have improved outcomes for most patients, MM remains an incurable disease characterized by continuous relapse. However, the treatment landscape for relapsed/refractory MM (RRMM) has expanded in recent years, and patients who relapse and/or become refractory to initial therapies are benefiting from the increasing availability of a diverse range of novel agents, including B-cell maturation antigen (BCMA)"targeted immunotherapies. These agents ... |
|
Unmasking Multiple Myeloma and Its Precursor Conditions in Primary Care
For multiple myeloma (MM) patients to receive the most appropriate care, a quick and accurate diagnosis is paramount. This is especially the case for Black patients, as diagnosis has historically been slower in Black patients"even though MM is twice as common in Black Americans than in White Americans. Additionally, MM precursor conditions such as monoclonal gammopathy of undetermined significance are seen more frequently in Black Americans than in White Americans. Primary care providers ... |
|
Across the Compendium: Practical Pathways to Integrate Bispecific Antibodies Into Care for Patients With Relapsed/Refractory Multiple Myeloma
As the armamentarium of therapies for relapsed/refractory multiple myeloma (R/R MM) expands, several factors, including previous therapy, treatment-related toxicity, and comorbidities must be considered as part of clinical decision making. To assist the multidisciplinary treatment team in these efforts, and ensure patients are receiving cutting-edge cancer care, this immersive digital practice guide highlights best practices, clinical pearls, and strategies to overcome pitfalls in the administ... |
|
Recognizing the Substantial Burden of Alopecia in Pediatric Patients and Building Multidisciplinary Capacity and Competence to Address Unmet Needs
Hair loss can have a profound psychological impact, especially on adolescents who may face social stigma or have self-esteem issues. Accurate diagnosis and appropriate management in this patient population can improve not only physical symptoms but also mental well-being.
If you’re a clinician who treats alopecia areata (AA) in pediatric patients, take your skills to the next level by accessing ACHL’s AdaptED® platform, which offers a tailored learning experience for busy clinicians, ... |
|
Top 10 Questions on Biomarkers in Early Alzheimer’s Disease: Improving Diagnosis and Use of Targeted Therapies
The past several years have seen numerous advances in Alzheimer’s disease (AD) diagnosis and management. Most recently, approval of antiamyloid monoclonal antibodies has revolutionized AD management and has required that patients have amyloid burden verified prior to initiating treatment. Biomarkers, whether obtained from cerebrospinal fluid (CSF) or positron emission tomography (PET) scans, are critical to the early diagnosis of AD and its subsequent management. Plasma biomarkers are an eme... |
|
Cleveland Clinic Multispecialty Pathology Symposium (online streaming & flash drive formats)
The Cleveland Clinic Multispecialty Pathology Symposium features an expert faculty addressing commonly encountered problems and providing practical tips from their own experience at the microscope. A broad spectrum of cases will be presented, reviewing genitourinary, pulmonary, gastrointestinal and soft tissue, gynecologic, and breast pathology. Participation in this activity will increase knowledge and improve performance in pathology, which will positively impact patient care.
Worth 16.... |
|
EBP/PBE: What Do I Do When There is No Evidence - Dr. Rik Lemoncello
This course provides learners with an understanding of the purpose, procedures, and limitations of evidence-based practice (EBP) in clinical decision-making applied to speech-language pathology. Participants will learn about the important role of practice-based evidence (PBE) and how it complements EBP to support management decisions for individual clients. Practical strategies and resources will be presented so that learners can implement course ideas immediately into practice. |
|
iPods, iPads, & iPhones, Oh My! Cognitive Rehab - Dr. Rik Lemoncello
This course is for those professionals working in adult acute and sub-acute rehabilitation settings. (The apps can also apply to those working with preteen/teens in any setting) The course will review accessibility options on an iDevice to support adults with cognitive challenges, describe methods to provide reminders or prompts to adults with memory challenges and describe methods to support attention or executive functioning for adults with cognitive challenges. |
|
Managing Speech and Swallowing with Trach/Ventilator Dependence - Rik Lemoncello, PhD, CCC-SLP
This workshop will provide SLPs with important information to understand, assess, and manage speech and swallowing challenges with adult patients who have tracheostomy tubes and/or use ventilators for respiratory support. Dr. Lemoncello will present in a dynamic format with hands-on demonstrations with tracheostomy tubes, ventilator circuits, and speaking valve placement. An adult living with a tracheostomy tube who uses a speaking valve and nighttime ventilator will also share her experiences... |
|
Therapy Tidbits – May/June 2017
COURSE ABSTRACT
Therapy Tidbits – May/June 2017 is a 1-hour online continuing education (CE) course comprised of select articles from the May/June 2017 issue of The National Psychologist, a private, independent bi-monthly newspaper intended to keep mental health professionals informed about practice issues. The articles included in this course are:
Advocates in Field of Aging Hear Strong Call to Action - Highlights focus points of the ASA conference in March: critical social and politic... |
|
Back to Basics: Typical Swallowing Physiology in Adults - Rik Lemoncello, PhD, CCC-SLP
This course will present current best information to help clinicians learn about typical aspects of oropharyngeal and esophageal swallowing in adults and older adults. This course is ideal for clinicians who need a refresher on typical adult swallowing, and is appropriate for SLP, OT, dietary, nursing, and other medical clinicians involved with interprofessional management of dysphagia. Information covered will include review of sensory and motor control of swallowing, timing and neurological ... |
|
Clinical Swallowing Evaluation for Adults - Dr. Rik Lemoncello
This course will present current best information to help clinicians learn about conducting and interpreting a clinical swallowing evaluation for adults in typical medical settings. This course will not discuss specific diagnoses or complex conditions such as tracheostomy/ventilator dependence. This course is ideal for clinicians who need a refresher on the purpose, procedures, observable signs/symptoms, and nature of recommendations that result from a clinical swallowing evaluation for adult ... |
|
Cyberbullying
Cyberbullying is a 2-hour online continuing education (CE/CEU) course that reviews evidenced-based research for identification, management and prevention of cyberbullying in children, adolescents, and adults.
Bullies have moved from the playground and workplace to the online world, where anonymity can facilitate bullying behavior. Cyberbullying is intentional, repeated harm to another person using communication technology. It is not accidental or random. It is targeted to a person with less... |
|
Mindfulness: The Healing Power of Compassionate Presence
Mindfulness: The Healing Power of Compassionate Presence is a 6-hour online continuing education (CE) course that will give you the mindfulness skills necessary to work directly, effectively, and courageously with your own and your clients' struggles.
Compassion towards others starts with compassion towards self. Practicing mindfulness cultivates our ability to pay intentional attention to our experience from moment to moment. Mindfulness teaches us to become patiently and spaciously aware ... |