|
Leveraging BCMA-Directed Therapies for Improved Patient Outcomes in Relapsed/Refractory Multiple Myeloma
STATEMENT OF NEED
Multiple myeloma is a disease that remains incurable for most patients, many of whom become refractory to the majority of available treatments (Kumar et al, 2022). It is estimated that 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Agents targeting B-cell maturation antigen (BCMA), including antibody-drug conjugates (ADCs), chimeric antigen receptor (CAR) T-cell therapies, and bis... |
|
|
Hitting the Target in HER2-Positive Metastatic Colorectal Cancer
STATEMENT OF NEED
An estimated 153,020 new cases of colorectal cancer (CRC) are diagnosed annually, and 52,550 people die of the disease (Siegel et al, 2023). Approximately 22% of patients present with metastatic disease, which is associated with a dismal 5-year survival rate of 15% (SEER, 2022). Targeting biomarkers is a key strategy for expanding therapeutic options and improving outcomes in metastatic CRC. Human epidermal growth factor receptor 2 (HER2) amplification status and treatment... |
|
|
Expert Guidance on Current Standards and New Directions in Newly Diagnosed Multiple Myeloma
STATEMENT OF NEED
An estimated 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Characterized by clonal proliferation of malignant plasma cells in the bone marrow, multiple myeloma is associated with anemia, renal insufficiency, bone destruction, and hypercalcemia, all of which significantly impact patients’ quality of life. The development of novel therapies and combinations in recent years, inclu... |
|
|
Pathology and Oncology Expert Perspectives in the Management of Triple-Negative Breast Cancer: Case Explorations and Answers to FAQs
STATEMENT OF NEED
Triple-negative breast cancer (TNBC) is an aggressive disease that accounts for approximately 10% to 15% of breast cancer diagnoses and is characterized by the absence of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2). TNBC is more common in Black women and in women under the age of 40 (ACS, 2023). Compared with other subtypes of invasive breast cancer, TNBC has high rates of metastasis and a poor prognosis. Due to the lack ... |
|
|
Managing Immune Related Adverse Events to Ensure Optimal Cancer Immunotherapy Outcomes: The Nurse’s View
STATEMENT OF NEED
Immune checkpoint inhibitors, which alter immune regulatory pathways and promote cell-mediated destruction of tumor cells, have revolutionized the treatment of cancer in recent years, with numerous therapeutic agents approved and several targets under investigation (Chennamadhavuni et al, 2022). However, up to 90% of patients receiving immune checkpoint inhibitors experience immune-related adverse events, which can affect a wide variety of organ systems and can occur at any ... |
|
|
Current Standards and New Directions in the Treatment of Acquired Thrombotic Thrombocytopenic Purpura
STATEMENT OF NEED
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare, life-threatening thrombotic microangiopathy with a rapid onset and progression and a mortality rate of 10% to 20% with prompt treatment. Onset of aTTP is characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, and a constellation of associated symptoms including hemorrhage, neurologic and renal manifestations, cardiac abnormalities, and mesenteric ischemia (Joly et al, 2017). Survivors of f... |
|
|
Recurrent and Metastatic HNSCC: New Insights and Real-World Evidence for Improved Patient Outcomes
STATEMENT OF NEED
Head and neck cancers represent a heterogeneous group of tumors that originate in the lip/oral cavity, hypopharynx, oropharynx, nasopharynx, and larynx. An estimated 66,470 new cases are diagnosed in the United States annually, and 15,050 people die of the disease (Siegel et al, 2022). Approximately 90% of cases are classified as head and neck squamous cell carcinoma (HNSCC). Treatment of HNSCC is complicated by numerous factors, including differing therapeutic strategies ... |
|
|
Diabetic Macular Edema: Employing Inflammatory Markers to Predict Improved Visual Outcomes
Real-world outcomes with intravitreal anti-vascular endothelial growth factor (VEGF) therapy in the treatment of patients with diabetic macular edema (DME) do not always replicate those seen in clinical studies. In part, these discrepancies are due to treatment burden, lack of adherence, undertreatment, and incomplete response to anti-VEGF therapies. The identification of several inflammatory cytokines in the aqueous and vitreous humor whose concentrations correlate closely with the severity o... |
|
|
Diabetic Macular Edema: Employing Inflammatory Markers to Predict Improved Visual Outcomes
Real-world outcomes with intravitreal anti-vascular endothelial growth factor (VEGF) therapy in the treatment of patients with diabetic macular edema (DME) do not always replicate those seen in clinical studies. In part, these discrepancies are due to treatment burden, lack of adherence, undertreatment, and incomplete response to anti-VEGF therapies. The identification of several inflammatory cytokines in the aqueous and vitreous humor whose concentrations correlate closely with the severity o... |
|
|
Best of Lipid Forum®: Examining the Role of Lp(a) as a Risk Factor in Atherosclerotic Cardiovascular Disease
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein particle that is associated with poor cardiovascular prognosis due to its pro-atherogenic, pro-thrombotic, pro-inflammatory and pro-oxidative properties. Unfortunately, traditional lipid-lowering therapy does not provide sufficient Lp(a) reduction. High levels of Lp(a) are an independent and causal risk factor for atherosclerotic cardiovascular disease (ASCVD) through mechanisms associated with increased atherogenesis, inflammation, and throm... |
|
|
Best of Lipid Forum®: Examining the Role of Lp(a) as a Risk Factor in Atherosclerotic Cardiovascular Disease
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein particle that is associated with poor cardiovascular prognosis due to its pro-atherogenic, pro-thrombotic, pro-inflammatory and pro-oxidative properties. Unfortunately, traditional lipid-lowering therapy does not provide sufficient Lp(a) reduction. High levels of Lp(a) are an independent and causal risk factor for atherosclerotic cardiovascular diseases (ASCVD) through mechanisms associated with increased atherogenesis, inflammation, and thro... |
|
|
Skin Cancer Education for Primary Care
This comprehensive course on skin cancer will help you improve your ability to diagnose and manage skin lesions, the most common of all cancers.
Outcome Objectives:
As a result of completing this activity, the participant will be better able to:
- Understand the biology of ultraviolet radiation and methods to protect the skin.
- Demonstrate increased proficiency in the management of potentially malignant skin lesions.
- Make early diagnoses of skin cancers, particularly melanoma.... |
|
|
COVID-19 Vaccine Myth Busters (Technician)
Recommendations regarding COVID-19 immunizations are being updated frequently. This session will discuss the safety and efficacy data available for the COVID-19 vaccines that have received an Emergency Use Authorization (EUA) from the Food and Drug Administration (FDA). Included in the discussion will be the mechanism of action and a comparison of dosage, schedule, and storage for the available COVID-19 vaccines. Patient cases to review recommended vaccines based on patient-specific factors an... |
|
|
COVID-19 Vaccine Myth Busters (Pharmacist)
Recommendations regarding COVID-19 immunizations are being updated frequently. This session will discuss the safety and efficacy data available for the COVID-19 vaccines that have received an Emergency Use Authorization (EUA) from the Food and Drug Administration (FDA). Included in the discussion will be the mechanism of action and a comparison of dosage, schedule, and storage for the available COVID-19 vaccines. Patient cases to review recommended vaccines based on patient-specific factors an... |
|
|
nAMD and DME Management: Rapid Response From ARVO
Real-world outcomes with anti-vascular endothelial growth factor (VEGF) therapies in the management of patients with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) are often not comparable to those of clinical studies. Discrepancies in these outcomes have been associated with undertreatment due to high treatment burden and the associated loss of patient adherence to dosing schedules. Newer therapies with novel mechanisms that extend intervals between dosing... |
|
|
nAMD and DME Management: Rapid Response From ARVO
Real-world outcomes with anti-vascular endothelial growth factor (VEGF) therapies in the management of patients with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) are often not comparable to those of clinical studies. Discrepancies in these outcomes have been associated with undertreatment due to high treatment burden and the associated loss of patient adherence to dosing schedules. Newer therapies with novel mechanisms that extend intervals between dosing... |
|
|
9th Annual Clinical Issues in Primary Care Conference
Presented by Continuing Education Company for over 30 years, our Primary Care CME Conference Series is designed to update primary care clinicians in rapidly changing therapeutic areas. The emphasis is on practical and useful information for clinical practice. Join us in May 2024 for our 9th Annual Clinical Issues in Primary Care Conference at the Fairmont Orchid, Hawaii Resort on the Big Island
Program Objectives
As a result of this conference, participants will be able to:
Assess and p... |
|
|
Parkinson’s Disease " Updates in Diagnosis and Patient Management
Parkinson's disease is a neurodegenerative disorder, second only in prevalence to Alzheimer’s disease. Numerous therapeutic options, including carbidopa/levodopa, monoamine oxidase-B inhibitors, dopamine agonists, and device-assisted therapies, are available for treatment. These treatments are indicated at different stages following diagnosis. However, Parkinson’s disease progresses at highly variable rates, and no biomarkers, laboratory tests, or gold standard indexes are available t... |
|
|
Diabetes Update 2024 - LIVE STREAMING
This highly rated Harvard Medical School CME course offers practical strategies to address the medical and systemic challenges to optimal care and updates that ensure you can deliver state-of-the-art care for your patients with diabetes.
PROGRAM HIGHLIGHTS
This program affords you the opportunity to learn from leaders in the field of diabetes who are distinguished for their outstanding teaching, knowledge, and innovations in clinical care.
Participants can rely on this program for compreh... |
|
|
Eyeing the Options for Treating Meibomian Gland Dysfunction and Dry Eye Disease
Dry eye disease (DED) is highly prevalent but frequently underdiagnosed and subsequently undertreated. Studies have demonstrated that meibomian gland dysfunction (MGD) is a leading cause of the development and progression of evaporative DED, caused by a deficient tear film lipid layer that leads to increased tear evaporation. New and emerging treatments with novel mechanisms of action are being investigated that manage the signs and symptoms of DED associated with MGD and offer the potential f... |
|
|
Case Challenges in nAMD and DME Management: Achieving Durable Response
The management of diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD) with intravitreal anti-vascular endothelial growth factor (VEGF) therapies has provided enhanced visual outcomes for many patients. However, the high treatment burden associated with anti-VEGF therapies can lead to lack of patient adherence, resulting in suboptimal outcomes. Personalized treatment protocols using FDA-approved agents and newer novel delivery systems, along with agents with uni... |
|
|
Sports Medicine 2024 -LIVE STREAMING
The Comprehensive 2024 Sports Medicine Update
State-of-the-Art Approaches to the Diagnosis, Treatment, Rehabilitation, and Prevention of Sports Injuries
This Harvard Medical School CME program, which is among the highest-rated HMS CME courses, provides a special and timely opportunity to hear directly from world-renowned physician specialists (physiatrists, orthopedists, radiologists), team physicians and athletic trainers for the Boston Red Sox, New England Revolution, and New England P... |
|
|
Meeting Milestones in nAMD and DME Management: What's New?
Anti-vascular endothelial growth factor (VEGF) therapy has revolutionized treatment paradigms for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). However, these agents are associated with a high treatment burden because of the injection frequency, and a substantial number of patients do not adhere to their treatment schedules, resulting in suboptimal response to therapy. To address these issues, new dosage regimens and surgical drug delivery approaches hav... |
|
|
WEBINAR: Data Gaps in Aquatic Pharmacology: Identifying Challenges and Needs
Administering medications to animals living in an aquatic environment poses unique challenges compared to their terrestrial counterparts. This talk will review the basic considerations when choosing and administering medication to fish and sharks and identify areas where we lack scientific data to support our medication choices. Medication behavior and its relationship to filtration and other environmental factors such as water pH, temperature, and alkalinity will also be covered.
This web... |
|
|
WEBINAR: The GRAS is Not Always Greener: Providing Toxin-free Drug Therapy to Animal Patients
Pharmacists and pharmacy technicians often are the last line of defense in recognizing and preventing potential animal poisoning. Unfortunately, pharmacists and pharmacy technicians traditionally are trained only in human toxicology. To provide competent and confident pharmaceutical care to non-human species, pharmacists and pharmacy technicians must possess a working knowledge of species-specific susceptibilities to toxins. Factors that affect the risk of toxicity vary greatly among species; ... |
|
|
32nd Annual Primary Care Conference, Session 1
Continuing Education Company has been organizing its Primary Care Conference Series for over 31 years. The Primary Care Conference is designed to update primary care clinicians in rapidly changing therapeutic areas. The emphasis is on practical and useful information for clinical practice. Join us this June or July when we hold the 32nd Annual Primary Care Conference. This conference will be repeated in two sessions for convenience in scheduling. Sessions I and II will be held at the Kiawah Is... |
|
|
Build Your Own Case Study | Obesity: Treating the Whole Patient
Activity Description
Obesity is a chronic, progressive, relapsing disease that impacts health and quality of life. In individuals with obesity, there are many contributors to its development and persistence, including lifestyle, social, and economic factors. If left untreated, obesity can be a primary driver of serious health consequences. By treating obesity first, complications arising from obesity may improve or resolve. Given the severity of the disease, there is a need for clinicians in ... |
|
|
Ace the Case: An 84-Year-Old Man With Neovascular Age-Related Macular Degeneration Receiving Bilateral Every 8-Week Anti-Vascular Endothelial Growth Factor Injections
In this clinical case review, Dr. Emmanuel Chang explores options to extend treatment intervals in a patient with stable nAMD who is receiving anti-VEGF therapy every 8 weeks. |
|
|
Ace the Case: A 76-Year-Old Male With Active Neovascular Age-Related Macular Degeneration
In this clinical case review, Dr. Arshad Khanani explores options for switching treatment in a patient with nAMD who has become nonresponsive to anti-vascular endothelial growth factor (VEGF) therapy. |
|
|
Major Depressive Disorder & Postpartum Depression: Targeting the GABA Deficit
Major depressive disorder (MDD), perinatal depression, and postpartum depression (PPD) are increasingly prevalent conditions that carry an extremely high disease burden. Underdiagnosis and undertreatment of major depressive episodes have led to significant unmet needs for these patient populations. Success of treatment with traditional antidepressants that target monoaminergic deficiencies and imbalances is limited by non- or incomplete therapeutic response as well as delayed onset of action. ... |
|
|
Navigating New Evidence in the Treatment of HER2-Expressing Metastatic Breast Cancer in Rural and Underserved Communities
Target Audience
This activity is designed specifically for oncologists, advanced practice providers, and other members of the healthcare team who serve patients from rural and underserved communities.
Program Overview
Over the past decades, the emergence of novel targeted therapies in combination with endocrine therapy has improved outcomes for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. However, oncology clinicians in rural and ... |
|
|
Lifestyle Medicine: Tools for Promoting Healthy Change - LIVE STREAMING
State-of-the-Art Approaches to Help Patients Initiate and Sustain Health-Promoting Behaviors
Lifestyle Medicine will be held online this year, using live streaming, electronic Q&A, and other remote learning technologies.
Overview
This immersive two-day course offers state-of-the-art strategies to guide patients to healthier lives. Education includes evidence-based strategies, tools and techniques to effect healthier changes in patients (and ourselves), including weight loss, exerci... |
|
|
32nd Annual Primary Care Conference, Session 2
Continuing Education Company has been organizing its Primary Care Conference Series for over 31 years. The Primary Care Conference is designed to update primary care clinicians in rapidly changing therapeutic areas. The emphasis is on practical and useful information for clinical practice. Join us this June or July when we hold the 32nd Annual Primary Care Conference. This conference will be repeated in two sessions for convenience in scheduling. Sessions I and II will be held at the Kiawah Is... |
|
|
15th Annual Essentials in Primary Care Summer Conference
Continuing Education Company has been organizing its Primary Care Conference Series for over 30 years. The Essentials in Primary Care Summer Conference is designed to update primary care clinicians in rapidly changing therapeutic areas. The emphasis is on practical and useful information for clinical practice. Join us this July when we hold the 15th Annual Essentials in Primary Care Summer Conference.
This conference will be held at the Hammock Beach Resort in Palm Coast, Florida. Located n... |
|
|
Pathways for Optimal Sequencing, Rapid Initiation, and Titration of Therapy in Patients with Heart Failure
Many patients with heart failure (HF) do not receive foundational treatment although these therapies reduce morbidity and mortality risks. The initiation and optimization of guideline-directed medical therapies (GDMT) can be challenging, but clinical practice guidelines and algorithms are available to assist.
Navigate through this interactive self-directed CME activity to apply the most recent clinical trial data and guidance to patient-specific factors seen in real-world practice. Expert p... |
|
|
Answers to the Questions You May Not be Asking: Treating Ulcerative Colitis Considerate of Patient-Centric Factors
Are you aware of the latest evidence-based strategies in ulcerative colitis (UC)? Looking to expand your ability to incorporate patient-centric factors into selection of therapy for UC? Navigate through this novel, interactive self-directed activity designed to optimize your decision making in selection of therapy for UC. View expert perspectives and insights who can help you apply newer strategies such as treat-to-target (T2T) and therapeutic drug monitoring (TDM) for the treatment for your ... |
|
|
Diabetes Mellitus Fundamentals: A Review and Current Update
The Diabetes Mellitus Fundamentals online course is a review of the basic information on the physiology and signs and symptoms of diabetes. It also contains updated resources and research on new findings related to DMT1 and DMT2. Participants will be able to indentify diabetes risk factors and discuss insulin and other methods of controlling diabetes. |
|
|
8th Annual Internal Medicine in Primary Care Conference
Continuing Education Company has been organizing its Primary Care Conference Series for over 30 years. The 8th Annual Internal Medicine in Primary Care Conference is designed to update primary care clinicians in rapidly changing therapeutic areas. The emphasis is on practical and useful information for clinical practice. Join us July 26 through August 2, 2024 when we host the 8th Annual Internal Medicine in Primary Care Conference on the Celebrity Edge while cruising Alaska and British Columbi... |
|
|
Cardiovascular Considerations in COPD Management
With cardiovascular disease coexisting in up to 60% of COPD cases, optimal management of each disease is imperative to successful patient outcomes. In this Phone-a-Friend episode, Dr. MeiLan Han consults with Dr. Ty Gluckman to discuss a patient with a 5-year history of COPD and cardiovascular risk factors that may be contributing to his persistent symptoms. |
|
|
The Art of Ophthalmology Medicine: Individualizing Therapy in Neovascular Age-Related Macular Degeneration in an Era of Expanded Treatment Options; AMD Virtual Pathways Activity
Target Audience
This initiative is designed to meet the educational needs of retina/ophthalmology, optometry, managed care, primary care/internal medicine, diabetes education, and cardiology/endocrinology sub-specialties.
Program Overview
This enduring activity focuses on individualizing therapy for the treatment of neovascular age-related macular degeneration (nAMD) based on patient-, disease-, and treatment-related factors. Listen to a retina expert talk about some of the technological ... |
|
|
Hitting The Bullseye in NSCLC
Lung cancer is the second most common cancer in both men and women and is the leading cause of cancer-related deaths. The majority of lung cancer cases are categorized as NSCLC, which has a low overall 5-year survival rate, especially when it is diagnosed at advanced, unresectable stages. Recent advances in the treatment landscape have yielded promising improvements in progression-free survival and overall survival; however, outcomes are dependent on numerous factors, including the evaluation ... |
|
|
Ready for a Closeup: Differentiating Inadequate Response and Emotional Blunting During Treatment for Major Depressive Disorder
Major depressive disorder (MDD) can have a significant impact on your patients’ lives. However, MDD is not just about feeling “down.” It’s a life-threatening condition that is a leading cause of suicide. Fortunately, there are a variety of effective therapies; however, many patients may experience an inadequate response to treatment and others may have experience anhedonia or reduced emotional responsiveness (ie, emotional blunting) associated with both selective serotonin reuptake inh... |
|
|
Applying Evolving Targeted Therapy in Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) is a biologically heterogeneous hematologic malignant neoplasm with a 5-year survival rate of 30%. Hematologist, Brian Jonas, MD, PhD, UC Davis Comprehensive Cancer, discusses standard induction, consolidation, and maintenance therapy, as well as factors to consider in individualizing intensive therapy in fit and unfit patients. Dr. Jonas presents safety and efficacy data for approved and emerging therapies that target BCL-2, FLT-3 ITD/TDK, CD33, CD47, IDH1/2, E-se... |
|
|
Contemporary Issues in the Management of Patients With Primary Biliary Cholangitis: An Interprofessional Approach
An interprofessional faculty of gastroenterology clinicians discuss real-world issues in managing patients with primary biliary cholangitis. Two mini-lectures serve as the foundation for understanding the diagnostic evaluation and risk factors of primary biliary cholangitis. Three cases foster a robust discussion, among the 5 faculty, of clinical decision-making around the roles, benefits, and limitations of approved and investigational pharmacologic treatment options. The program format foste... |
|
|
6th Annual Women's Health Conference
Join women's health professionals from around the country at the 6th Annual Women's Health Conference on September 30 - October 2, 2024 at the The Meritage Resort & Spa. This conference has been accredited for up to 15 CME credits by a variety of medical organizations. More accreditation details...
This conference will focus on timely and practical issues involving women’s health. An emphasis will be placed on recent advances, up-to-date practices, and guidelines that will e... |
|
|
LET'S TALK: Tackling Complex Issues Regarding SM-AHN Management A Monday Morning Joe Online Educational Activity
Systemic mastocytosis (SM) is a group of rare disorders characterized by the accumulation of mast cells in internal tissues and organs. The pathogenesis of SM is linked to a characteristic exon 17 D816V mutation of the KIT gene. Systemic mastocytosis with associated hematologic neoplasms (SM-AHN) is an advanced subtype of SM that is associated with a shortened median survival time. Recent advances in the SM therapeutic landscape have led to the development of KIT-targeted treatment options; ho... |
|
|
Irregular Care: Racial Inequities in the Management of Cardiac Rhythm Disorders
Structural racism and classism leads to many of the social determinants of health (SDoH) that cause disparities in cardiovascular (CVD) care, such as unequal preventative care, heart arrythmia treatment, and research inclusion. Interpersonal racism, including unconscious bias, worsens disproportionate CVD care, and is also a stand-alone factor for this health inequity. Underrepresented minority (URM) patients – particularly Black/African American individuals – are less likely to receive, b... |
|
|
Case Studies in HIV Prevention and Treatment of Persons Who Use Drugs
Educational Need:
Prevention of HIV in individuals with substance use disorder (SUD) is vitally important from a public health perspective. People with SUD are significantly more vulnerable to contracting HIV, attributable to behaviors such as sharing needles and injection equipment, engaging in condomless sex, and impaired judgement. Furthermore, substance use can negatively affect medication adherence and engagement in healthcare, making it more challenging to treat and manage HIV in this ... |
|
|
Surgery or Biologic for Nasal Polyps? A Close Look at the Evidence
Target Audience
The intended audience for this program is ENTs, allergists, immunologists, specialty nurse practitioners and PAs, and other clinicians involved in the management of patients with nasal polyps.
Program Overview
As management strategies for nasal polyps (NPs) have evolved, patients whose NPs do not respond to initial treatment, who are ineligible for systemic corticosteroids, or whose NPs recur after initial surgery often undergo repeated surgeries, with high associated cost... |
|
|
Cleveland Clinic Interprofessional Approach to Liver Disease (Online Streaming & USB Formats)
The management of critically ill patients with liver disease requires the expertise of a variety of healthcare providers from multiple disciplines. Cleveland Clinic addresses their multifaceted educational needs with the Interprofessional Approach to Liver Disease. Physicians, nurses and physician assistants will benefit from the latest strategies and evidence based management guidance from an expert faculty. Worth 14 AMA PRA Category I Credits™, with ANCC and AAPA accreditation provided a... |
|