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Novel Breast Cancer Therapies: Immune Checkpoint Inhibitors
STATEMENT OF NEED
Breast cancer is the most common cancer diagnosed in women, and it is
estimated that 12% of cases are classified as triple-negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) (ACS, 2019). Immune checkpoint inhibition in combination with chemotherapy is a new strategy in breast cancer, with the first immunotherapy approval for patients with advanced triple-negative disease occurring in 2019. Immune checkpoint inhibit... |
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Oncology Data Advisor™: Aligning Treatment Goals and Value-Based Care in Newly Diagnosed Multiple Myeloma
STATEMENT OF NEED
Multiple myeloma is a clonal plasma cell malignancy characterized by several cytogenetic alterations. Treatment planning for individual patients is complicated by factors such as age, frailty, comorbidities, eligibility for autologous stem cell transplantation, and risk stratification (Kumar et al, 2022). Clinicians need to continually update their working knowledge of emerging data and consensus recommendations that can rationally inform clinical decision making. In Modul... |
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Medical Crossfire: Optimizing Outcomes for Patients with Stroke: Secondary Prevention and Risk Reduction
Activity Overview
Stroke is the fifth leading cause of death in the United States and the second leading cause of death worldwide. Ischemic stroke, which is caused by obstruction in a blood vessel supplying blood to the brain, is the most common type of stroke, accounting for 87% of strokes globally. Most patients who experience an ischemic stroke or transient ischemic attack (TIA) should be managed with risk-reduction strategies. Such strategies, known as secondary prevention, include lifest... |
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Rheumatoid Arthritis: A Pharmacist's Guide to Patient Management
With 1.3 million Americans currently diagnosed with Rheumatoid Arthritis, this specialty condition often finds itself being managed in multiple sites of care. This activity will provide updates on the disease, pathophysiology, treatment algorithms, and role of the pharmacist in the overall care and management of the RA patient. |
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Multi-Cancer Early Detection in the Primary Care Setting
TARGET AUDIENCE:
The target audience for this curriculum are primary care physicians, internal medicine, and related health care professionals involved in screening patients for cancer. Health-care professionals may be unfamiliar with the concept of patient-centered care models that provide optimal outcomes for screening patients for cancer.
PROGRAM OVERVIEW:
Module 1 covers cancer screening: now and in the future.
Module 2 covers MCED: economics, applications in primary care settings.... |
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Eosinophilic Esophagitis: Novel Therapeutic Developments and Impact on Treatment Paradigms
Eosinophilic esophagitis (EoE) is a chronic, type-2 helper (Th2)-mediated inflammatory disorder that affects both children and adults. It is characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. Once considered rare, EoE is a relatively new disease that is now commonplace. When left unmanaged, EoE can impact a patient’s ability to eat properly, leading to food impaction and increased medical expenses. Real-world data indicate that m... |
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Eosinophilic Esophagitis: Novel Therapeutic Developments and Impact on Treatment Paradigms
Eosinophilic esophagitis (EoE) is a chronic, type-2 helper (Th2)-mediated inflammatory disorder that affects both children and adults. It is characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. Once considered rare, EoE is a relatively new disease that is now commonplace. When left unmanaged, EoE can impact a patient’s ability to eat properly, leading to food impaction and increased medical expenses. Real-world data indicate that m... |
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Collaborating Across the Continuum™: Taking IgA Nephropathy Management to the Next Level
Target Audience
This activity is intended for nephrologists, primary care providers, specialty pharmacists, managed care professionals, nurse practitioners, physician assistants, registered nurses, and other members of the IgAN care team.
Activity Overview
Immunoglobulin (Ig) A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, and it is considered a significant cause of end-stage renal disease (ESRD) in young adults. The precise pathogenesis of IgAN remai... |
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The DETECT Initiative in Early Alzheimer’s Disease: Optimizing Collaboration and Multidisciplinary Care to Facilitate Timely Diagnosis Grand Rounds Series
Target Audience
This activity is designed to meet the educational needs of U.S.-based community healthcare providers who care for patients with AD, including primary care clinicians, neurologists, geriatricians, geriatric psychologists, psychiatrists, pharmacists, and managed care professionals.
Program Overview
This Enduring of the DETECT Grand Rounds connects specialists with on-the-ground community HCPs to educate them on best practices for managing patients with early cognitive impair... |
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Pathways to Developing Personalized Treatment Regimens for Patients with Advanced Melanoma
No two patients with advanced melanoma are the same and tailoring treatment is vital. Immerse yourself in this interactive “choose your path” digital algorithm with expert perspectives to assist with the application of new guidelines and treatment options to optimize therapy.
Do you have questions about treating patients with advanced melanoma? Do you wonder…
• When to use immune checkpoint inhibitors (ICIs), and in which combinations?
• How to select among the growing number o... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Vitamin A & Carotenoids
Vitamin A is the name of a group of fat-soluble retinoids, primarily retinol and retinyl esters. Vitamin A is involved in immune function, cellular communication, growth and development, and male and female reproduction. Vitamin A supports cell growth and differentiation, playing a critical role in the normal formation and maintenance of the heart, lungs, eyes, and other organs. Vitamin A is also critical for vision as an essential component of rhodopsin, the light-sensitive protein in the ret... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Home Study Bundle
Individuals often rely on their pharmacists for advice on the selection and use of nutritional supplements. Yet, many pharmacists practicing today did not enjoy a comprehensive study of vitamins and minerals in their academic education. And those who did may be unaware of recent study findings that have expanded our understanding of how deficiencies and excesses of certain micronutrients may affect health status " and how micronutrients may interact unfavorably with certain medications.
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Thiamin (B1)
Thiamin (or thiamine) is one of the water-soluble B vitamins. It is also known as vitamin B1. Thiamin is naturally present in some foods, added to some food products, and available as a dietary supplement. This vitamin plays a critical role in energy metabolism and, therefore, in the growth, development, and function of cells.
Want to learn more? Click below to get access to our learning materials on Thiamin (B1) and receive 1-hour of accredited continuing education. |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Vitamin E
Vitamin E is found naturally in some foods, added to others, and available as a dietary supplement. “Vitamin E” is the collective name for a group of fat-soluble compounds with distinctive antioxidant activities.
Want to learn more? Click below to get access to our learning materials on Vitamin E and receive 1-hour of accredited continuing education. |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Vitamin K
“Vitamin K,” the generic name for a family of compounds with a common chemical structure of 2-methyl-1,4-naphthoquinone, is a fat-soluble vitamin that is naturally present in some foods and is available as a dietary supplement. These compounds include phylloquinone (vitamin K1) and a series of menaquinones (vitamin K2). Menaquinones have unsaturated isoprenyl side chains and are designated as MK-4 through MK-13, based on the length of their side chain. MK-4, MK-7, and MK-9 are the most wel... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Vitamin D
Vitamin D (also referred to as “calciferol”) is a fat-soluble vitamin that is naturally present in a few foods, added to others, and available as a dietary supplement. It is also produced endogenously when ultraviolet (UV) rays from sunlight strike the skin and trigger vitamin D synthesis.
Want to learn more? Click below to get access to our learning materials on Vitamin D and receive 2-hours (0.2 CEUs) of accredited continuing education. |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Riboflavin (B2)
Riboflavin (also known as vitamin B2) is one of the B vitamins, which are all water-soluble. Riboflavin is naturally present in some foods, added to some food products, and available as a dietary supplement. This vitamin is an essential component of two major coenzymes, flavin mononucleotide (FMN; also known as riboflavin-5’-phosphate) and flavin adenine dinucleotide (FAD). These coenzymes play major roles in energy production; cellular function, growth, and development; and metabolism of fa... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Vitamin C
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. Humans, unlike most animals, are unable to synthesize vitamin C endogenously, so it is an essential dietary component.
Want to learn more? Click below to get access to our learning materials on Vitamin C and receive 1-hour of accredited continuing education. |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Niacin (B3)
Niacin (also known as vitamin B3) is one of the water-soluble B vitamins. Niacin is the generic name for nicotinic acid (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside. Niacin is naturally present in many foods, added to some food products, and available as a dietary supplement.
Want to learn more? Click below to get access to our learning materials on Niacin (B3) and receive 1-hour of accredited cont... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Pantothenic (B5)
Pantothenic acid (also known as vitamin B5) is an essential nutrient that is naturally present in some foods, added to others, and available as a dietary supplement. The main function of this water-soluble B vitamin is in the synthesis of coenzyme A (CoA) and acyl carrier protein. CoA is essential for fatty acid synthesis and degradation, transfer of acetyl and acyl groups, and a multitude of other anabolic and catabolic processes. Acyl carrier protein’s main role is in fatty acid
synthesis... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Vitamin B6
Vitamin B6 is a water-soluble vitamin that is naturally present in many foods, added to others, and available as a dietary supplement. It is the generic name for six compounds (vitamers) with vitamin B6 activity: pyridoxine, an alcohol; pyridoxal, an aldehyde; and pyridoxamine, which contains an amino group; and their respective 5’-phosphate esters. Pyridoxal 5’ phosphate (PLP) and pyridoxamine 5’ phosphate (PMP) are the active coenzyme forms of vitamin B6. Substantial proportions of the... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Biotin (B7)
Biotin, a B vitamin, is an essential nutrient that is naturally present in some foods and available as a dietary supplement. This water-soluble vitamin is a cofactor for five carboxylases (propionyl-CoA carboxylase, pyruvate carboxylase, methylcrotonyl-CoA carboxylase [MCC], acetyl-CoA carboxylase 1, and acetyl-CoA carboxylase 2 that catalyze critical steps in the metabolism of fatty acids, glucose, and amino acids. Biotin also plays key roles in histone modifications, gene regulation (by modi... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Folate (B9)
Folate is a water-soluble B vitamin that is naturally present in some foods, added to others, and available as a dietary supplement. “Folate,” formerly known as “folacin” and sometimes “vitamin B9,” is the generic term for naturally occurring food folates, and folates in dietary supplements and fortified foods, including folic acid. Food folates are in the tetrahydrofolate (THF) form and usually have additional glutamate residues, making them polyglutamates. Folic acid is the fully... |
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THE MICRONUTRIENTS: Survey of 13 Vitamins, Deficiencies, Supplements, and Interactions: Vitamin B12
Vitamin B12 is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement and a prescription medication. Because vitamin B12 contains the mineral cobalt, compounds with vitamin B12 activity are collectively called “cobalamins”. Methylcobalamin and 5-deoxy adenosylcobalamin are metabolically active forms of vitamin B12. However, two other forms, hydroxocobalamin and cyanocobalamin become biologically active after they are converte... |
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Therapy Tidbits Summer 2022
Therapy Tidbits " Summer 2022 is a 1-hour online continuing education (CE) course comprised of select articles from the Summer 2022 issue of The National Psychologist, a private, independent, quarterly newspaper intended to keep psychologists informed about practice issues.
The articles included in this course are:
Mental Health 988 Emergency Lifeline Makes National Debut " Celebrates the nationwide availability of the 988-emergency phone number.
Minnesota Oversight Process La... |
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