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Novel Breast Cancer Therapies: Antibody-Drug Conjugates
STATEMENT OF NEED
Breast cancer is the most common cancer diagnosed in women, with an estimated 15% of cases being human epidermal growth factor receptor 2 (HER2)"positive and 12% being triple-negative (ACS, 2019). Antibody-drug conjugates have revolutionized the treatment of HER2-positive, triple-negative, and, most recently, HER2-low unresectable or metastatic breast cancer. These drugs combine a tumor antigen"targeted monoclonal antibody with a cytotoxic payload to permit the s... |
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Novel Breast Cancer Therapies: Immune Checkpoint Inhibitors
STATEMENT OF NEED
Breast cancer is the most common cancer diagnosed in women, and it is
estimated that 12% of cases are classified as triple-negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) (ACS, 2019). Immune checkpoint inhibition in combination with chemotherapy is a new strategy in breast cancer, with the first immunotherapy approval for patients with advanced triple-negative disease occurring in 2019. Immune checkpoint inhibit... |
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Novel Breast Cancer Therapies: CDK4/6 Inhibitors
STATEMENT OF NEED
Breast cancer is the most common cancer diagnosed in women, with 287,850 new cases and 43,250 deaths predicted to occur in 2022 (ACS, 2022). Making up 73% of cases, hormone receptor (HR)"positive/human epidermal growth factor receptor 2 (HER2)"negative disease is the most common subtype of breast cancer (ACS, 2019). Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are a novel therapeutic option for patients with HR-positive, HER2-negative advanced breast cancer. T... |
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Novel Breast Cancer Therapies: HER2 Tyrosine Kinase Inhibitors
STATEMENT OF NEED
Breast cancer is the most common cancer diagnosed in women, and it is estimated that 15% of cases are HER2-positive and may therefore benefit from human epidermal growth factor receptor 2 (HER2) inhibition (ACS, 2019). By blocking downstream oncogenic signaling in HER2-positive breast cancer cells, HER2 tyrosine kinase inhibitors improve outcomes for patients with HER2-positive breast cancer. These agents have advantages over monoclonal antibody HER2 inhibitors because the... |
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Novel Breast Cancer Therapies: Monoclonal Antibodies
STATEMENT OF NEED
Breast cancer is the most common cancer diagnosed in women, and it is estimated that 15% of cases are human epidermal growth factor receptor 2 (HER2)"positive and may therefore benefit from HER2 inhibition (ACS, 2019). Monoclonal antibodies target HER2 function by preventing the formation or blocking the signaling of the oncogene HER2. The resulting loss of signaling downregulates oncogenic signaling in the cancer cell, resulting in improved clinical outcomes for pati... |
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Novel Breast Cancer Therapies: PARP Inhibitors
STATEMENT OF NEED
Breast cancer is the most commonly diagnosed cancer in women. A BRCA1 or BRCA2 mutation is found in approximately 5% of patients with breast cancer and is detected in 30% of patients who have a family history of breast or ovarian cancer (ACS, 2019). In patients with human epidermal growth factor receptor 2 (HER2)"negative breast cancer with deleterious or suspected deleterious germline BRCA mutations, inhibition of poly"(ADP-ribose) polymerase (PARP) is highly ef... |
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Novel Breast Cancer Therapies: PI3K Inhibitors
STATEMENT OF NEED
Breast cancer is the most diagnosed cancer in women, with hormone receptor (HR)"positive/human epidermal growth factor receptor 2 (HER2)"negative breast cancer being the most common subtype, making up 73% of cases (ACS, 2019). In breast cancer, phosphatidylinositol-3-kinase (PI3K) overactivation is often associated with an activating mutation in the catalytic alpha subunit of PI3K (PIK3CA). These activating mutations occur in more than one third of breast cancers... |
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Growth Hormone Deficiency Research Highlights
This 15-minute CME program highlights the latest clinical research about Growth Hormone Deficiency (GHD).
GHD is a rare endocrine disorder characterized by insufficient levels of growth hormone being secreted from the anterior pituitary gland. A hallmark of prolonged GHD is growth retardation or deceleration, as well as short stature. Additionally, growth hormone deficiency is associated with metabolic abnormalities, impaired cardiovascular function, fatigue, delayed or incomplete puberty, ... |
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PAH Research Highlights from CHEST
PAH is a rare, progressive disorder characterized by high blood pressure in the pulmonary arteries. Symptoms of PAH include shortness of breath (dyspnea) especially during exercise, chest pain, and fainting episodes. The progressive nature of this disease means that an individual may experience only mild symptoms at first, but will eventually require treatment and medical care to maintain a reasonable quality of life. There are numerous treatment options and options in development for persons ... |
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Evolving Treatment Concepts and New Data in Advanced Prostate Cancer
STATEMENT OF NEED
Prostate cancer is the most common tumor type affecting men in the United States. It is estimated that 268,490 new cases were diagnosed and that 34,500 people died of prostate cancer in 2022 (Siegel et al, 2022). Prostate cancer alone accounts for 27% of all cancer diagnoses in men (ACS, 2022). To optimize outcomes for patients with prostate cancer, it is critical for health care providers to be familiar with the most recent evidence on therapy selection, biomarker testing... |
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Cracking the Code for Improved Patient Outcomes in Advanced Renal Cell Carcinoma
STATEMENT OF NEED
Renal cell carcinoma (RCC) comprises 2.4% of malignancies in adults worldwide (Makino et al, 2022). It is estimated that 79,000 new cases of kidney cancer were diagnosed in the US in 2022 (Siegel et al, 2022). RCC is characterized by a lack of early warning signs, diverse clinical manifestations, and resistance to radiation and chemotherapy. Several new therapies have been approved for RCC in recent years; therefore, it is important for the cancer care team to update their... |
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Oncology Data Advisorâ„¢: Aligning Treatment Goals and Value-Based Care in Newly Diagnosed Multiple Myeloma
STATEMENT OF NEED
Multiple myeloma is a clonal plasma cell malignancy characterized by several cytogenetic alterations. Treatment planning for individual patients is complicated by factors such as age, frailty, comorbidities, eligibility for autologous stem cell transplantation, and risk stratification (Kumar et al, 2022). Clinicians need to continually update their working knowledge of emerging data and consensus recommendations that can rationally inform clinical decision making. In Modul... |
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Virtual Tumor Board: Building Comprehensive Care Plans in Esophagogastric Cancers
STATEMENT OF NEED
Esophagogastric cancers include tumors of the esophagus, esophageal junction, and stomach. Esophageal cancers are the twentieth most commonly diagnosed cancer in the United States, but the eleventh leading cause of cancer death, with an estimated 21,560 cases diagnosed annually and 16,120 deaths estimated in 2023 (NCCN, 2023; Siegel et al, 2023). Given the poor prognosis of esophagogastric cancers and the complexity of personalized care planning, interdisciplinary teamwork... |
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Fabry Disease Research Highlights
This 30-minute CME-accredited program highlights the latest clinical research about Fabry disease, a rare X-linked lysosomal disorder that results in the cellular buildup of globotriaosylceramide. Characteristic features of Fabry disease include acroparesthesias, angiokeratomas, hypohidrosis, corneal opacity, gastrointestinal problems, tinnitus, and hearing loss. Fabry disease also involves potentially life-threatening complications such as progressive kidney damage, heart attack, and stroke.
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Hitting the Target in HER2-Positive Metastatic Colorectal Cancer
STATEMENT OF NEED
An estimated 153,020 new cases of colorectal cancer (CRC) are diagnosed annually, and 52,550 people die of the disease (Siegel et al, 2023). Approximately 22% of patients present with metastatic disease, which is associated with a dismal 5-year survival rate of 15% (SEER, 2022). Targeting biomarkers is a key strategy for expanding therapeutic options and improving outcomes in metastatic CRC. Human epidermal growth factor receptor 2 (HER2) amplification status and treatment... |
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Building and Maintaining a Multidisciplinary Team for Lysosomal Disorders
This CME/CE activity with Drs. Ozlem Goker-Aplan and Walla Al-Hertani describes the importance of a multidisciplinary team approach to managing lysosomal diseases, as well as some of the challenges involved in creating and maintaining that team.
At the end of this activity, participants should be able to:
- Describe the need for a team approach to care
- Describe best practices to build a multidisciplinary team for a new patient
- Describe best practices to maintain a multidisciplinary... |
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Myasthenia Gravis Research Highlights: AAN 2023
This 30-minute CME program highlights the latest clinical research about myasthenia gravis, a rare, autoimmune disease that targets the neuromuscular junction.
Treatment of myasthenia gravis is highly individualized and depends greatly on the myasthenia gravis subtype of each patient as well as each patient’s comorbidities. There are currently four drugs approved by the FDA, eculizumab, efgartigimod, ravulizumab, and rozanolixizumab. There are also treatments in development. Clinical tria... |
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Leveraging the Growing Arsenal of Adjuvant Therapies for Early-Stage NSCLC
In this activity, Dr. Helena A. Yu, Associate Attending Physician at Memorial Sloan Kettering Cancer Center, will provide insights into strategies for leveraging the growing arsenal of adjuvant therapies for early-stage non"small cell lung cancer (NSCLC), including treatment selection and adverse event management. Start the activity now!
STATEMENT OF NEED
Lung cancer is the second most commonly diagnosed cancer and the leading cause of death for men and women worldwide. In the Unite... |
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Pathology and Oncology Expert Perspectives in the Management of Triple-Negative Breast Cancer: Case Explorations and Answers to FAQs
STATEMENT OF NEED
Triple-negative breast cancer (TNBC) is an aggressive disease that accounts for approximately 10% to 15% of breast cancer diagnoses and is characterized by the absence of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2). TNBC is more common in Black women and in women under the age of 40 (ACS, 2023). Compared with other subtypes of invasive breast cancer, TNBC has high rates of metastasis and a poor prognosis. Due to the lack ... |
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Virtual Tumor Board: Multidisciplinary Management of Advanced Soft Tissue Sarcoma
STATEMENT OF NEED
Sarcomas, which represent 1% to 2% of adult cancers, are a rare, heterogeneous group of neoplasms originating in the connective tissue. Soft tissue sarcomas, which begin in the muscle, tendons, fat, lymph, blood vessels, and nerves, encompass more than 80 histological subtypes. Approximately 25% of patients develop metastatic disease after curative-intent surgery, and for these patients, treatment options are limited and prognosis is very poor. In recent decades, the ident... |
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Putting the Freeze on Cold Agglutinin Disease
STATEMENT OF NEED
Cold agglutinin disease (CAD) is a rare subtype of autoimmune hemolytic anemia (AIHA) in which antibodies cause hemolysis at cold temperatures, generally between 37º to 39º Fahrenheit. Approximately 1 in a million people are affected by CAD annually, with onset usually occurring between the ages of 40 and 80 years. Individuals commonly experience fatigue, dizziness, palpitations, and shortness of breath caused by the anemia; jaundice caused by degradation of hemoglobin i... |
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Managing Patients with Rheumatic Disorders in Primary Care
Rheumatic disorders are prevalent, yet their diagnosis and treatment in affected patients are frequently challenging, contributing to a considerable disease burden. Ensuring timely intervention is critical to slow disease progression and improve patient outcomes. However, various educational gaps impede primary care clinicians from effectively achieving these goals. This 0.75-hour text-based activity features 3 modules comprised of 12 questions encountered in the primary care management of pat... |
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Acromegaly Research Highlights: ENDO 2023
This 30-minute CME-accredited program highlights the latest clinical research about acromegaly, a rare endocrine disorder. Common symptoms include subtle skeletal overgrowth; soft tissue swelling (tongue, heart, kidney, colon, and vocal cords); unusually prominent forehead and heavy brow ridge; protruding lower jaw; overbite; skin thickening; increased shoe and ring size; hypertension; increased perspiration; headaches; paresthesia; and sexual dysfunction.
There are several orphan drugs app... |
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Managing Immune Related Adverse Events to Ensure Optimal Cancer Immunotherapy Outcomes: The Nurse’s View
STATEMENT OF NEED
Immune checkpoint inhibitors, which alter immune regulatory pathways and promote cell-mediated destruction of tumor cells, have revolutionized the treatment of cancer in recent years, with numerous therapeutic agents approved and several targets under investigation (Chennamadhavuni et al, 2022). However, up to 90% of patients receiving immune checkpoint inhibitors experience immune-related adverse events, which can affect a wide variety of organ systems and can occur at any ... |
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Exploring New Treatment Advances for Acid Sphingomyelinase Deficiency in Adults
STATEMENT OF NEED
Acid sphingomyelinase deficiency (ASMD) is a rare, hereditary lysosomal storage disease with multisystemic manifestations, including splenomegaly, hepatomegaly, interstitial lung disease, dyslipidemia, bone marrow and lymph node involvement, and sometimes neurological and peripheral nerve involvement. While the most severe form of ASMD, infantile neurovisceral ASMD, results in death in early childhood, chronic forms of ASMD have more prolonged survival but are associated w... |
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Current Standards and New Directions in the Treatment of Acquired Thrombotic Thrombocytopenic Purpura
STATEMENT OF NEED
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare, life-threatening thrombotic microangiopathy with a rapid onset and progression and a mortality rate of 10% to 20% with prompt treatment. Onset of aTTP is characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, and a constellation of associated symptoms including hemorrhage, neurologic and renal manifestations, cardiac abnormalities, and mesenteric ischemia (Joly et al, 2017). Survivors of f... |
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Recurrent and Metastatic HNSCC: New Insights and Real-World Evidence for Improved Patient Outcomes
STATEMENT OF NEED
Head and neck cancers represent a heterogeneous group of tumors that originate in the lip/oral cavity, hypopharynx, oropharynx, nasopharynx, and larynx. An estimated 66,470 new cases are diagnosed in the United States annually, and 15,050 people die of the disease (Siegel et al, 2022). Approximately 90% of cases are classified as head and neck squamous cell carcinoma (HNSCC). Treatment of HNSCC is complicated by numerous factors, including differing therapeutic strategies ... |
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Best Practices in Nursing Management of Chemotherapy-Induced Peripheral Neuropathy
STATEMENT OF NEED
Chemotherapy-induced peripheral neuropathy (CIPN) is a complication of cancer treatment that may impair quality of life and lead to dose reductions or discontinuation of treatment. In one study, among 105 patients receiving paclitaxel for breast cancer, 36.2% needed dose reductions due to CIPN (Timmins et al, 2021). Whereas in some patients the symptoms improve with time, in others, there is progression with permanent nerve damage (ZajÄ…czkowska et al, 2019). At present, the... |
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Applying the Latest Clinical Data in Multiple Myeloma Patient Care in the Community Setting
In recent years, there have been significant advances in multiple myeloma (MM) management, including approvals of new drugs and treatment combinations. For some patients, however, the benefits of these advances remain elusive: disparities in MM care among Black patients, who are more likely to be treated in the community setting, persist across the spectrum of MM care.
Though evidence-based MM treatment guidelines and consensus statements are available, ongoing studies continue to provide i... |
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Controversies & Advances in the Treatment of Cardiovascular Disease, the Twenty-First in the Series
We look forward to the twenty-first Controversies and Advances in the Treatment of Cardiovascular Disease symposium and to returning to the beautiful Beverly Hills Hotel this November 30 - December 1, 2023!
The two-day scientific program will offer realistic views on many controversial issues in cardiovascular disease today. A faculty of internationally known leaders share their knowledge and experiences with complex and controversial cases. |
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GOCCNJ Summit: Improving Quality Care for People with Serious Illness
Did you know that New Jersey patients near the end of life are treated with more aggressive medical care than patients in any other state in the U.S.?
This high-intensity, high-cost care is often unwanted and burdensome to both patients and their caregivers. Key reasons for this burdensome care are the lack of knowledge about palliative and end-of-life care services, and comfort discussing these care options with patients.
This program consists of presentations and breakout sessions with... |
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Overview of the 2023 GOLD Guidelines for COPD
Target Audience
The educational design of this activity addresses the needs of primary care providers (PCPs), including physicians, nurse practitioners, and physician assistants who manage patients with chronic obstructive pulmonary disease (COPD).
Program Overview
During the first activity of the series, expert faculty will present and discuss key updates to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Report for Prevention, Diagnosis, and Management of COPD. Th... |
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Strategies and Pathways Targeting Domains in the Treatment of Psoriatic Disease
TARGET AUDIENCE:
This activity has been designed to address the educational needs of rheumatology and dermatology clinicians. It may also be of benefit to other clinicians interested in the care of patients who have psoriatic disease
PROGRAM OVERVIEW:
Psoriatic disease is a complex disease in which musculoskeletal and cutaneous inflammation occurs alongside hyperproliferation of both bone and skin. Patients have heterogeneous presentations of disease activity across 6 domains: Psoriasis, pe... |
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PrEParing to End the Epidemic: Optimizing HIV Prevention in Primary Care
This educational program will focus on how to identify and engage with patients at high risk for HIV infection, use nonjudgmental communication skills to remove the stigma associated with HIV, and foster meaningful discussions about sexual health and behavior. It will also provide practical clinical information on implementing PrEP services in primary care practice, including the safety and efficacy of oral and long-acting injectable PrEP agents, initiating and monitoring patients on PrEP, and... |
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Ensuring Gender-Affirming Health Care for Transgender and Gender-Diverse Youth
Transgender youth see higher rates of suicide, poorer health outcomes, and an overall lack of access to quality care. In this expert interview, join pediatrician and child psychiatrist, Jason Rafferty, MD, MPH, EdM, from the Warren Alpert Medical School of Brown University, on a path to ensuring equitable and comprehensive healthcare for transgender and gender diverse youth. Ensure your transgender and gender diverse youth patients are receiving the care they deserve. |
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Case Studies in Major Depressive Disorder: A Focus on Emotional Blunting and Inadequate Treatment Response
Two common problems that primary care providers encounter when treating patients with MDD are (1) inadequate treatment response and (2) adverse effects, such as emotional blunting, associated with antidepressants. In addition to compromising a patient’s health and quality of life, these problems cause many individuals with MDD to not adhere to a treatment plan. In this activity, 2 expert faculty members, W. Clay Jackson, MD, DipTh, and Regina F. Goulder, FNP-C, APN, will support learners as ... |
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Nursing Management of Cancer Treatment-Induced Cardiotoxicity
Studies have shown that certain cancer therapies adversely affect the heart and lead to various types of injuries, which often result in death. This activity reviews recent advances in the management of cancer teatment-induced cardiotoxicity.
STATEMENT OF NEED
Several studies reveal that certain cancer therapies adversely affect the heart and lead to various types of injuries, which often result in death. Adverse cardiac effects may occur immediately after cessation of therapy or, in som... |
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Case Studies in HIV Prevention Among Communities at High Risk for HIV
Case Studies in HIV Prevention Among Communities at High Risk for HIV
Release Date: December 23, 2022
Expiration Date: December 23, 2023
Estimated Time to Complete: 1.0 hour
VIEW ACTIVITY
Support for this activity has been made possible through educational grants from Gilead Sciences, Merck, Theratechnologies, and ViiV Healthcare.
Educational Need:
Access to HIV prevention, including preexposure prophylaxis (PrEP) continues to improve. Despite this progress, PrEP access remains... |
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Improving Selection and Utilization of Continuous Glucose Monitors (CGM) for People with Diabetes
Self-monitoring of blood glucose (BG) levels is critical to daily self-management for people with diabetes. Studies have shown that intensive insulin regimens and BG control corresponded with better glycemic control have resulted in a significant decrease in the microvascular complications of diabetes. Because CGM is still an evolving technology, both clinicians and patients would benefit from engaging, interactive, and evidence-based education to improve the utilization of these tools. |
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AnesthesiaFile
- Affordable CE - 60 credit package
- CE as low as $3.75 per credit
- Monthly continuing education subscription
- Latest findings/trends in the field of Anesthesia
- Articles pulled from peer-reviewed medical journals
- Digital and downloadable PDF versions are available​
- Accurate and timely reporting of CME/CE credits
- AnesthesiaPodâ„¢ available |
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PainFile
- 20 Abstracted articles per month
- An extensive review of pain management literature
- Articles pulled from peer-reviewed medical journals
- Up-to-date and clinically relevant
- Online and mobile-friendly
- 40 CME credits per subscription |
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Updates on Pain Review: Conversations with the Experts - Neuromodulation
Learning Objectives:
Describe techniques of performing spinal cord stimulation trial and implantation procedures.
Describe indications, contraindications, and mechanism of actional of spinal cord stimulation.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a dearth of comprehensive educational programming. The Updates on Pain Review: Conversations with the Experts curriculum has been designed to provide the latest adj... |
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Updates on Pain Review: Conversations with the Experts - Introduction to Regenerative Medicine, Osteoarthritis & Cartilage Health Regenerative Medical Therapies
Learning Objectives:
Describe the role of subchondral bone marrow in cartilage health.
Describe the catabolic role of local anesthetics.
Explain the role of chondrocytes in cartilage health.
Describe the catabolic role of corticosteroids.
Describe the role of regenerative medicine for orthopedic conditions.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a dearth of comprehensive educational programming. The Updates ... |
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Updates on Pain Review: Conversations with the Experts - "Psychogenic" Pain
Learning Objectives:
Define DSM IV/V diagnoses.
Discuss recording the impact of various factors of pain perception.
Describe psychogenic pain.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a dearth of comprehensive educational programming. The Updates on Pain Review: Conversations with the Experts curriculum has been designed to provide the latest adjustments to pain management practices and improve the practitionerâ... |
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Updates on Pain Review: Conversations with the Experts - Psychological Assessment of Pain
Learning Objectives:
List the most common assessment tools and procedures.
Define the relationship pain mechanism and assessment of pain.
Define and highlight concerns with treating different patient populations.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a dearth of comprehensive educational programming. The Updates on Pain Review: Conversations with the Experts curriculum has been designed to provide the latest ... |
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Updates on Pain Review: Conversations with the Experts - Function, Impairment, Disability, & Handicap
Learning Objectives:
Define impairment according to varied sources and discuss related measurement scales.
Define function and functionality and discuss related measurement scales.
Define disability (activity limitation) according to varied sources and discuss related measurement scales.
Briefly discuss physical medicine treatment options related to activity limitations and participation restrictions.
Define handicap (participation restriction) according to varied sources.
When prepa... |
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Updates on Pain Review: Conversations with the Experts - Trigger Points & Peripheral Joint Injections
Learning Objectives:
Define the terms tender point and trigger point and identify the treatment solutions for both.
Describe the indications for, contraindications of, and appropriate exercise regimens for peripheral injections in the vicinity of the shoulder, elbow, wrist/hand, hip, knee, ankle/foot.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a dearth of comprehensive educational programming. The Updates on Pain R... |
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Updates on Pain Review: Conversations with the Experts - Rehabilitation Medicine Approach to Chronic Pain Management
Learning Objectives:
Describe the role of the following modalities in the treatment of chronic pain: heat, cold, electricity, manual (osteopathic) manipulation and mobilization, massage, traction, splinting/orthotic devices, and exercise.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a dearth of comprehensive educational programming. The Updates on Pain Review: Conversations with the Experts curriculum has been designe... |
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Updates on Pain Review: Conversations with the Experts - Opioids, REMS, Prescription Writing
Learning Objectives:
Appreciate how the basis of the REMS program has changed with the changing opioid epidemic.
Present a framework for best practices regarding opioid management in pain patients and introduce basic science and clinical research in opioid therapy.
Review the history of the REMS program.
Consider the scope of the opioid epidemic past and present.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a deart... |
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Updates on Pain Review: Conversations with the Experts - Steroids, Anti-Depressants, and Anti-Convulsants
Learning Objectives:
Review contraindications to therapy.
Present a framework for best choices based on goals and patient physiology.
Review the pharmacology and physiology of antidepressants.
Review the pharmacology and physiology of steroid medication.
Review the pharmacology and physiology of anticonvulsants.
When preparing to take the pain board examination, both for initial certification and for recertification, there is a dearth of comprehensive educational programming. The Upd... |
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