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Expert Guidance on New Advances in Renal Cell Carcinoma
STATEMENT OF NEED
Kidney cancer accounts for approximately 4% of all cancer diagnoses in the United States (ACS, 2020). An estimated 73,750 new cases are reported annually and 14,830 people die of the disease. Renal cell carcinoma, which comprises nearly 90% of all kidney cancers, is characterized by a lack of early warning signs, diverse clinical manifestations, and resistance to radiation and chemotherapy. Due to its often asymptomatic presentation, many patients have advanced disease at ... |
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Virtual Tumor Board: Optimizing Personalized Care Plans for Patients With Metastatic Breast Cancer
STATEMENT OF NEED
Breast cancer accounts for approximately 30% of cancer diagnoses among women in the United States and is the second-leading cause of cancer death in this population (ACS, 2020). Although many women benefit from regular screening as well as earlier and improved treatment, approximately 6% present with metastatic disease, and up to 30% with no initial lymph node involvement eventually develop metastatic disease (Siegel et al, 2020; Mortensen et al, 2018). Women with metastat... |
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Virtual Tumor Board: Optimizing Personalized Care Plans for Patients With Relapsed/Refractory Follicular Lymphoma
STATEMENT OF NEED
Of the estimated 74,200 new cases of non-Hodgkin lymphoma each year in the United States, approximately 22% are FL, an indolent, difficult-to-treat B-cell malignancy (ACS, 2019; NCCN, 2019). Most patients are diagnosed at an average age of 63 years (NCI, 2019). Despite the introduction of novel therapies during the past decade, complications such as delayed presentation and treatment and evolving disease subtypes continue to hamper patient outcomes, and multiple recurrence... |
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Virtual Tumor Board: Optimizing Personalized Care Plans for Patients With Advanced Soft Tissue Sarcoma
STATEMENT OF NEED
Soft tissue sarcomas are a heterogeneous group of malignancies that arise primarily from the mesodermal tissues of the extremities, trunk and retroperitoneum, and head and neck. An estimated 13,130 new cases are diagnosed in the United States annually and 5,350 people die of the disease. Surgical resection is the mainstay of treatment for localized soft tissue sarcoma, with radiation and chemotherapy commonly used as adjuncts. However, nearly 50% of patients will experienc... |
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Navigating the Recent Rheumatoid Arthritis Guidelines to Achieve Disease Remission and Reduce Patient
Roy M. Fleischmann, MD, discusses the latest evidence for the management of patients with moderate-to-severe rheumatoid arthritis who do not achieve treatment goals with initial disease-modifying anti-rheumatic drug therapy. A key treatment principle emphasized by Dr. Fleischmann is using a treat-to-target approach guided by validated tools for assessing disease activity and patient-reported outcomes. Among the treatment options, Dr. Fleischmann highlights the pharmacology of the latest approv... |
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Navigating Advancements in Diagnosis & Treatment of Axial Spondyloarthritis
More than 80% of the population has significant back pain at some point in their life, with 30% of adults in the United States stating they have chronic low back pain at any given time; 5% of whom have inflammatory back pain. Axial spondyloarthritis (axSpA) affects almost 1.5% of patients with inflammatory back pain; however, the majority of individuals suffering with back pain are not being treated by a rheumatologist, which only exacerbates the challenge to diagnose those with axSpA.
Dr.... |
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Research Developments in Atopic Dermatitis
Welcome to this activity focusing on new research related to atopic dermatitis presented as posters at the 2020 virtual annual meetings of the American Academy of Dermatology and the American Academy of Allergy, Asthma, and Immunology. The posters focus on new data related to the use of advanced therapies for atopic dermatitis. Beyond discussing the methods and results of each poster, the faculty, Drs. Steven Feldman and Alan Fleischer, Jr., share their views on the implication of the trial re... |
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Defining Personalized Care Plans in Metastatic Colorectal Cancer
STATEMENT OF NEED
Colorectal cancer (CRC) is the third leading cause of cancer death among men and women in the United States. An estimated 145,600 new cases are diagnosed annually and 51,020 people die of the disease. When detected and treated early at a localized stage, the 5-year survival rate is 90%. However, because CRC initially exhibits no symptoms and the use of routine screening is suboptimal, most patients are diagnosed at later stages. Approximately 21% of patients present with m... |
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Right Patient, Right Treatment, Right Time: Utilizing Early, High-Efficacy Therapies to Improve Outcomes in RRMS
Recent studies have demonstrated the benefits of early and aggressive treatment strategies in reducing disability progression and the frequency of relapses in patients with relapsing remitting multiple sclerosis (RRMS), marking a paradigm shift in the treatment of patients with RRMS. The traditional escalation approach is now often set aside in favor of the more individualized "induction" approach, which utilizes "early and aggressive" treatment with high-efficacy disease-modifying therapies (... |
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Beyond the Old Paradigms: Novel Approaches to the Treatment of Chronic Idiopathic Constipation
Chronic idiopathic constipation (CIC) affects 35 million adults in the United States, making it one of the most common gastrointestinal disorders. Despite the high prevalence, CIC is often underdiagnosed and undertreated, which exacts a functional, psychosocial, and economic toll on patients and their loved ones. The current treatment goal in CIC is multi-symptom relief, but only 16% of patients with CIC are on prescription therapy, and they often only obtain partial relief, with many using la... |
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Giving Shingles Immunization Your Best Shot: Implementing a Shingles Vaccination Protocol in Your Practice
Shingles, or herpes zoster, is a common secondary infection for older patients. Almost all individuals over the age of 50 are latently infected with varicella zoster virus (VZV) and therefore are at risk of developing shingles with reactivation of latent VZV. Individuals who develop shingles often experience debilitating postherpetic neuralgia (PHN), secondary skin infections, eye problems, or neurologic conditions including an increased risk of stroke.
Despite the existence of vaccines, th... |
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Retooling for Modern Management of Progressive MS: An Interactive, Case-Based Activity
The approval of ocrelizumab for primary progressive multiple sclerosis (PPMS) was groundbreaking, and more recently the MS community bore witness to another major breakthrough in MS management when siponimod was approved for secondary progressive MS (SPMS). Additionally, new investigational agents such as MD1003 (high-dose biotin) and masitinib are also being evaluated for treatment of PPMS, and clinical data for both show promise for patients with SPMS.
However, despite these advances, stu... |
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Looking Ahead: Integrating Emerging Therapies and Tools in Early-Stage Alzheimer's Disease
Alzheimer's disease (AD), a heterogeneous, neurodegenerative condition with an insidious onset and slow progression, is the leading cause of disability and morbidity as well as the sixth-leading cause of death in the United States. Diagnosing AD is often complicated due to its varied clinical symptomatology and unknown etiology, and currently only symptomatic therapies are available.
Recent clinical trials investigating disease-modifying therapies (DMTs) that could slow or reverse the progr... |
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Hitting the Target with IL-23 Inhibitors in Psoriatic Arthiritis
Psoriatic arthritis (PsA) is a chronic, inflammatory, musculoskeletal disease with a significant impact on quality of life and functional ability. Despite the data showing the overall impact of PsA, delays in diagnosis are common, which can lead to long-term joint damage and functional disability.
In this CME Outfitters Live and OnDemand activity, expert faculty will focus on assessment, treatment, and management strategies to provide patients with the best treatment aligned with evolving e... |
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Keeping the Beat: Screening and Management of High-Risk Patients with Non-Valvular Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, projected to affect 12 million Americans by 2030. However, a significant number of AF cases, particularly non-valvular atrial fibrillation (NVAF) remain undiagnosed, putting patients at risk for severe cardiovascular (CV) complications, including increased risk of stroke. It is imperative that clinicians identify the symptomatology of AF and effectively diagnose NVAF, as these complications can potentially be avoided by ... |
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Targeted Therapy for HER2 and HER3-Positive Breast Cancer: Navigating the Evolving Treatment Landscape
Statement of Need
Breast cancer (BC) is a heterogeneous disease with human epidermal growth factor receptor 2 (HER2) overexpression and/or amplification observed in 20%-30% of cases. HER2-positive (+) BC correlates with poor clinical outcomes unless appropriately treated with targeted therapy. Despite significant therapeutic advances, many patients experience disease progression with resistance to targeted agents developing over the course of treatment.
This CME Outfitters Live and OnDe... |
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Tumor-induced Osteomalacia (TIO): Diagnosis and Management
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic condition commonly characterized by bone pain, muscle weakness and fractures. These tumors secrete excess fibroblast growth factor 23 (FGF23) which inhibits the sodium phosphate renal co-transporters and suppresses 1α hydroxylase activity, thereby decreasing renal reabsorption and increased urinary phosphate excretion. As a result, unexplainable hypophosphatemia with a variety of musculoskeletal abnormalities are the most common sympto... |
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Neuroendocrine Tumors (NETs) Research Highlights from ENDO 2020
Although the 2020 Endocrine Society’s annual meeting (ENDO 2020) did not take place as scheduled, abstracts, including new information and data on neuroendocrine tumors (NETs) were published. This CME activity highlights the latest information about NETs from ENDO 2020 and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with these rare diseases. |
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Exploring Novel Treatment Strategies for Metastatic Colorectal Cancer
STATEMENT OF NEED
Colorectal cancer (CRC) is the third leading cause of cancer death among men and women in the United States. An estimated 145,600 new cases are diagnosed annually and 51,020 people die of the disease. When detected and treated early at a localized stage, the 5-year survival rate is 90%. However, because CRC initially exhibits no symptoms and the use of routine screening is suboptimal, most patients are diagnosed at later stages. Approximately 21% of patients present with m... |
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Clinical Updates and Expert Guidance in Prostate Cancer
STATEMENT OF NEED
Prostate cancer is the most common tumor type affecting men in the United States, with an estimated 174,650 new cases reported each year. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be understood and represents a significa... |
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Virtual Tumor Board: Diagnosis and Management of Myelodysplastic Syndromes
STATEMENT OF NEED
Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic disorders derived from an abnormal multipotent progenitor cell, characterized by ineffective hematopoiesis, bone marrow failure, and peripheral blood cytopenias. Survival in MDS ranges from a median of 5.3 years in lower-risk patients to as little as 0.8 years in higher-risk patients. Mortality is usually a result of infection, hemorrhage, and/or iron overload secondary to red blood cell transfusion... |
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Mucopolysaccharidoses (MPSs) Highlights from WORLDSymposium 2020
At WORLDSymposium 2020, new information and data were presented on Mucopolysaccharidoses (MPSs), a group of genetic lysosomal disorders. This CME activity highlights the latest information about MPSs from WORLDSymposium and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with these rare diseases. |
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Gaucher Disease Highlights from WORLDSymposium 2020
At WORLDSymposium 2020, new information and data were presented on Gaucher disease, a rare lysosomal storage disorder. This CME/CNE activity highlights the latest information about Gaucher disease from WORLDSymposium and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with this rare disease. |
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Fabry Disease Highlights from WORLDSymposium 2020
At WORLDSymposium 2020, new information and data were presented on Fabry disease, a rare lysosomal storage disorder. This CME/CNE activity highlights the latest information about Fabry disease from WORLDSymposium and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with this rare disease. |
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@MondayNightIBD OnDemand: Addressing the Cases That Challenge Your Practice
Statement of Need
Gastroenterologists are trailblazers in health care social media, and #MondayNightIBD (#MNIBD) has harnessed that energy to establish gastroenterologists as not just social media influencers but as clinical practice influencers as well. #MNIBD is not just a weekly social media conversation - it is an international platform that is moving the field forward by crowdsourcing the expertise of leading inflammatory bowel disease (IBD) experts, community clinicians, and patients ... |
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Improving the Quality of Care for Patients with Atopic Dermatitis: Integrating Measurement-Based Tools Into Your Clinical Practice
Statement of Need
Attitudes about atopic dermatitis are evolving with the emergence of new and effective treatments. With the average dermatologist having not enjoyed caring for patients with AD for decades, there is little to no consensus in current practice about validated tools to assess and monitor the severity of the diseases and no consistent use of diagnostic or assessment tools. This lack of knowledge and education leads to confusion, poor recognition, and absence of assessment of AD ... |
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Navigating the New Psoriasis Guidelines: Implications for Clinical Practice
Statement of Need:
The American Academy of Dermatology (AAD) and the National Psoriasis Foundation (NPF) have recently released new joint guidelines that outline best practices for the management of psoriasis (PsO) with biologics, the need for awareness and attention to comorbidities, and guidelines for pediatric PsO treatment. Clinicians must ensure that they are aware of these guidelines and of strategies to incorporate them into clinical practice, including the integration of biologic ther... |
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At-Risk Patients Hidden in Plain Sight: Real-World Strategies for Screening and Treating Hepatitis B Virus
Statement of Need
Chronic hepatitis B virus (HBV) remains a global epidemic, resulting in significant morbidity and mortality. In 2015, there were 257 million people worldwide infected with HBV. In 2016, only 10.5% were diagnosed, with only 16.7% receiving treatment, and without intervention, there are 19 million deaths anticipated by the end of 2020. These numbers are startling as they exist despite the availability of effective treatment, and this is in part due to lack of clinician knowl... |
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A Deeper Dive into NASH Diagnosis and Treatment: An Augmented Reality Experience
Statement of Need
Obesity and diabetes are on the rise, leading to an increased prevalence of non-alcoholic fatty liver disease (NAFLD), which in some cases may progress to non-alcoholic steatohepatitis (NASH). NAFLD effects approximately 30% of the U.S. population, with NASH effecting about 5%. NASH comes with a significant risk of progression to advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Disease models project that the number of individuals with end-stage live... |
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What the Future Holds for NASH: An Augmented Reality Look into Disease Stating and Targeted Therapies
Statement of Need
Given the rising prevalence of non-alcoholic fatty liver disease (NAFLD) and the societal and economic burden of its aggressive subtype, non-alcoholic steatohepatitis (NASH), it is important that hepatologists and gastroenterologists are equipped with the latest tools to diagnose NASH. While there are currently no approved therapies for the treatment of NASH, several targeted therapies are being investigated in clinical trials, with high probability of being approved in the ... |
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Addressing the Burden of Psoriatic Arthritis: Moving Beyond the Joint
Philip J. Mease, MD, and Alexis R. Ogdie-Beatty, MD, review the pathogenesis and a wide spectrum of clinical features, manifestations, and comorbidities of psoriatic arthritis; talk about classification criteria for PsA and different patient-reported and provider-assessed outcome measures; and discuss treatment recommendations and strategies, as well as various types of current and emerging therapies. Finally, they highlight some of the key issues and challenges of the management of PsA throug... |
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Shifting Focus: Individualizing Preventive Therapy for Hereditary Angioedema
William Lumry, MD, FACAAI, discusses the genetic component of HAE and differences among the types of HAE. This activity also includes several eye-opening video clips from patients with HAE who describe how it affects their daily lives.
Content Areas:
• Burden of disease
• Clinical presentation, features
• Causes and types
• Diagnosis and screening
• Approaches to treatment
• Preventive treatment
• Comprehensive treatment
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Optimizing Personalized Care Plans for Patients With Advanced Non-Small Cell Lung Cancer
STATEMENT OF NEED
An estimated 228,150 new cases of lung cancer are reported in the United States annually, and 142,670 people die of the disease. The major subtypes are non-small cell (84%) and small cell (13%). Most patients with lung cancer are diagnosed at a locally advanced or metastatic stage, making systemic therapy the cornerstone of management. Although 70% of patients receiving first-line classical doublet chemotherapy demonstrate clinical benefit, most develop progressive disea... |
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PILOTforPulmonary 2019: Data, Insights & Practice
This education provides the opportunity to learn the latest in the management of patients with IPF/ILD. Summaries or abstracts from recent pulmonary meetings will be presented followed by video discussions by expert faculty regarding the implications on the management of patients with IPF/ILD. Skills can then be applied in an interactive case where the learner is challenged to make decisions for the patient. |
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New Thinking, New Strategies in Advanced Urothelial Carcinoma
STATEMENT OF NEED
Bladder cancer is the sixth most common malignancy among adults in the United States. Approximately 80,470 new cases are diagnosed annually and 17,670 people die of the disease. More than 90% of patients with bladder cancer have the urothelial carcinoma subtype, which has a high rate of recurrence whether it is low or high grade. Approximately half of all bladder cancers are diagnosed in situ, for which the 5-year relative survival rate is 95%. For tumors diagnosed as a lo... |
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TTR Amyloidosis
By learning more about the pathophysiology of rare diseases like TTR Amyloidosis, members of the care team who may encounter these patients on their diagnostic journeys can have a profound impact on their ultimate outcomes. |
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Clinical Insights on Recent Advances in Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a leading, fatal, autosomal recessive disorder that affects approximately one in 10,000 live births. Nusinersen was approved as the first targeted therapy for SMA, and since its groundbreaking approval data has been published that demonstrates its efficacy for both infantile- and later-onset SMA populations. Additionally, recent guidelines were published that provide evidence-based recommendations for the diagnosis and management of SMA.
However, despite the... |
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Food Allergy: From Primary Prevention to Treatment and Intervention Online
This online offering includes 19 videos of lectures and panel discussions on the diagnosis and management, specific syndromes, treatment, and research and prevention of food allergy. The videos were recorded at a live course that took place at a live AAAAI course held in early September, 2019.
The intent of the videos is to allow learners to increase their knowledge related to the diagnosis and management of food allergic patients. It highlights the latest evidence related to food allergie... |
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Conversations from the World of Allergy: Podcast Episodes for Credit
This podcast features interviews on a wide variety of allergy/immunology topics. It is our hope that the conversations provide evidence-based information that is useful to clinicians, researchers and patients, alike.
Some episodes are available for CME credit. All podcast episodes are available at https://www.aaaai.org/professional-education-and-training/podcasts |
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Virtual Patient: Asthma in the Older Adult
This patient simulation requires an evaluation and creation of a treatment plan for an older adult (>65 years old) with asthma. The case involves identification of differences and similarities between asthma and COPD in older adults and consideration of medications and co-morbid conditions that may complicate the management of asthma in this population. A summary of the literature supporting best practices in asthma care in the older adult will be provided. |
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The CARES Approach: Improving Glycemic, Cardiovascular, and Renal Outcomes
Target Audience
This educational activity is intended for cardiologists, endocrinologists, primary care physicians, NPs, PAs, nurses, and other clinicians involved in the treatment of patients with type 2 diabetes mellitus (T2DM).
Program Overview
This case-based enduring simulcast will cover the treatment and management of patients with type 2 diabetes mellitus.
Learning Objectives
Upon completion of this activity, participants should be able to:
Personalize the selection of thera... |
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Community Practice Connections™: HPV: Points of Prevention in Primary Care
Target Audience
This educational activity is directed toward family practice providers who treat patients who are candidates for HPV vaccination. Physicians, nurse practitioners, nurses, pharmacists, and other health care professionals interested in HPV vaccination are invited to participate.
Activity Overview
Human papillomavirus (HPV) is responsible for more than 40,000 cases of cancer in the United States annually. Though HPV vaccines have been available for approximately 15 years, bel... |
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Can We Talk: Strategies to Communicate Long-Acting Injectables (LAIs) as an Effective Treatment Option for Bipolar I Disorder
This CME Outfitters BriefCase utilizes a patient case to guide clinicians on best practices to engage patients in treatment planning for BD-I, including the feasibility of LAIs as an effective treatment option.
At the end of this CE activity, participants should be able to:
-Incorporate collaborative care discussions with patients with bipolar I disorder that include incorporating LAIs as a potential management option.
The following learning objectives pertain only to those requesting C... |
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Missed Opportunities: Tools, Tips, and Techniques to Improve the Detection of Bipolar I Disorder
In this CME Outfitters BriefCase, expert faculty will present a patient case that shows how to detect BD-I, differentiate BD-I and BD-II and other mimickers, and use evidence-based screening tools to improve detection of BD-I in order to promote early administration of effective care.
At the end of this CE activity, participants should be able to:
-Implement diagnostic criteria and evidence-based tools to improve detection of bipolar I disorder for early administration of effective care.
... |
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Advances In: Best Practices in RA Management – Applying the Evidence to Optimize Treatment Decision-Making
Target Audience
This educational activity is directed toward rheumatologists, specialty nurse practitioners, specialty physician assistants, family physicians/primary care physicians, and additional health care providers involved in the treatment and management of patients with RA.
Activity Overview
This online educational activity is designed to provide expert interpretation of new and emerging data on the treatment of rheumatoid arthritis (RA), with a forward-looking perspective on ... |
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Vaccination Needs in Older Populations
Older adults are especially susceptible to vaccine-preventable illnesses and vaccine recommendations have been updated to reflect recent advances that impact older people. Clinicians who care for, or interact with, older adults can be advocates for vaccination and should be familiar with the most recent changes to vaccine schedules. Additionally, it’s important that clinicians understand the impact of COVID-19 on vaccinations among older vulnerable patients, and how to reduce their risk for ... |
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When Is Switching ART Necessary?
In this CME Outfitters BriefCase, faculty will highlight a patient case that focuses on seizing opportunities to optimize and simplify treatment for patients with human immunodeficiency virus (HIV) while maintaining virologic suppression, as well as best practices for engaging patients in shared decision-making so that patient preference is always considered.
At the end of this CE activity, participants should be able to:
-Determine appropriate strategies for treatment switching.
The fo... |
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Oral Ondansetron Offers Effective Antidiarrheal Activity for Carcinoid Syndrome Refractory to Somatostatin Analogues
Somatostatin analogs (SSAs) are standard for
symptomatic patients with neuroendocrine tumors (NETs).
However, most patients experience tachyphylaxis, and limited options exist for this so-called “refractory carcinoid
syndrome.” Recently, 5-HT3 antagonist ondansetron has
been associated with reduction of bowel movement in a
small series. The aim of this analysis was to assess effectiveness of ondansetron for symptomatic treatment of carcinoid syndrome.
Implications for Practice: Som... |
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Weighing the Evidence: A Pharmacy Approach to Stroke Prevention in Obese Patients with Non-Valvular Atrial Fibrillation
In this CME Outfitters virtual symposium, expert faculty will review key aspects of the prescribing information, guidelines, and recently published safety and efficacy data for DOACs and warfarin in order to enable pharmacists and other clinicians to support evidence-based therapeutic treatment decisions in obese patients with NVAF.
At the end of this CE activity, participants should be able to:
-Assess existing guidelines and U.S. prescribing information for use of DOACs and warfarin to p... |
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Risk for Opioid Overdose: Identifying At-Risk Patients in Your Practice Hidden in Plain Sight
The objective of this webcast is to raise awareness about the risk of overdose among patients with chronic pain in everyday practice and actionable changes to practice that are needed to mitigate that risk.
At the end of this CE activity, participants should be able to:
-Recognize the distinct patient profiles of individuals at risk of opioid overdose
-Initiate discussions about overdose risk with chronic pain patients prescribed high dose opioids (= 50 MME)
-Co-prescribe and counsel chr... |
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