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Leveraging BCMA-Directed Therapies for Improved Patient Outcomes in Relapsed/Refractory Multiple Myeloma
STATEMENT OF NEED
Multiple myeloma is a disease that remains incurable for most patients, many of whom become refractory to the majority of available treatments (Kumar et al, 2022). It is estimated that 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Agents targeting B-cell maturation antigen (BCMA), including antibody-drug conjugates (ADCs), chimeric antigen receptor (CAR) T-cell therapies, and bis... |
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Hitting the Target in HER2-Positive Metastatic Colorectal Cancer
STATEMENT OF NEED
An estimated 153,020 new cases of colorectal cancer (CRC) are diagnosed annually, and 52,550 people die of the disease (Siegel et al, 2023). Approximately 22% of patients present with metastatic disease, which is associated with a dismal 5-year survival rate of 15% (SEER, 2022). Targeting biomarkers is a key strategy for expanding therapeutic options and improving outcomes in metastatic CRC. Human epidermal growth factor receptor 2 (HER2) amplification status and treatment... |
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Expert Guidance on Current Standards and New Directions in Newly Diagnosed Multiple Myeloma
STATEMENT OF NEED
An estimated 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Characterized by clonal proliferation of malignant plasma cells in the bone marrow, multiple myeloma is associated with anemia, renal insufficiency, bone destruction, and hypercalcemia, all of which significantly impact patients’ quality of life. The development of novel therapies and combinations in recent years, inclu... |
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Exploring New Treatment Advances for Acid Sphingomyelinase Deficiency in Adults
STATEMENT OF NEED
Acid sphingomyelinase deficiency (ASMD) is a rare, hereditary lysosomal storage disease with multisystemic manifestations, including splenomegaly, hepatomegaly, interstitial lung disease, dyslipidemia, bone marrow and lymph node involvement, and sometimes neurological and peripheral nerve involvement. While the most severe form of ASMD, infantile neurovisceral ASMD, results in death in early childhood, chronic forms of ASMD have more prolonged survival but are associated w... |
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Cleveland Clinic State of the Art Echocardiography (Online & DVD-ROM)
Cleveland Clinic’s State of the Art Echocardiography highlights practical issues in echocardiography, featuring insight and real world cardiovascular clinical practice cases from nearly 30 internationally renowned experts. This activity provides guidance for optimal utilization of echocardiography in managing valvular heart disease, heart failure, device therapies, cardiomyopathies and endocarditis. Special sessions will be dedicated to structural heart interventions, adult congenital cardi... |
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Office Practice of Primary Care Medicine 2024 - LIVE STREAMING
The Comprehensive 2024 Update on Office-Based Primary Care Medicine
Taught Live Online by Harvard Medical School's Leading Clinical Faculty
Office Practice of Primary Care Medicine will be held online this year, using live streaming, electronic Q&A, and other remote learning technologies.
OVERVIEW
Office Practice of Primary Care Medicine provides comprehensive reviews of the most important recent advances impacting primary care medicine and guidance to assimilate these changes... |
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Operation Game- A Patient’s Journey Through HeFH: Diagnosis and Management
Target Audience
This activity has been designed to address the educational needs of cardiologists, cardiology nurses, lipid specialists, and primary care clinicians, including internists, pharmacists, nurses, nurse practitioners, PAs, and dietitians. It may also benefit other healthcare providers who manage patients with hypercholesterolemia.
Program Overview
Nonstatins are an essential therapy for lowering low-density lipoprotein cholesterol (LDL-C) levels in high-risk patients, such as ... |
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Advancing the Care of Patients Living with EGPA Through Multidisciplinary, Patient-Focused Care
Target Audience
This educational activity is intended for rheumatologists, allergists, immunologists, pulmonologists, and specialty advance practice clinicians who care for patients with EGPA.
Program Overview
The comprehensive program provides up-to-date information regarding EGPA"its recognition, diagnosis, and treatment"and incorporates the patient perspective to raise awareness of patients’ needs, heighten urgency, and, ultimately, educate on the disease. The program will ... |
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nAMD and DME Management: Rapid Response From ARVO
Real-world outcomes with anti-vascular endothelial growth factor (VEGF) therapies in the management of patients with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) are often not comparable to those of clinical studies. Discrepancies in these outcomes have been associated with undertreatment due to high treatment burden and the associated loss of patient adherence to dosing schedules. Newer therapies with novel mechanisms that extend intervals between dosing... |
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nAMD and DME Management: Rapid Response From ARVO
Real-world outcomes with anti-vascular endothelial growth factor (VEGF) therapies in the management of patients with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) are often not comparable to those of clinical studies. Discrepancies in these outcomes have been associated with undertreatment due to high treatment burden and the associated loss of patient adherence to dosing schedules. Newer therapies with novel mechanisms that extend intervals between dosing... |
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Introduction to Musculoskeletal Ultrasound - Blended
The Blended Introduction to Musculoskeletal Ultrasound Training Course provides participants a comprehensive introduction to upper and lower extremity musculoskeletal ultrasound for diagnostic applications and ultrasound guided injection/aspiration techniques. The Blended Education format provides flexibility while providing time and cost savings.
Begin with the self-paced online course: Taught by leading musculoskeletal ultrasound experts, the online course incorporates comprehensive lectu... |
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Peripheral Nerve Ultrasound - Blended
The Blended Peripheral Nerve Ultrasound Course is designed to provide a comprehensive approach to the use of ultrasound for the assessment and treatment of peripheral nerves. The Blended Education format provides flexibility while providing time and cost savings.
Begin with the self-paced online course: Taught by leading peripheral nerve and musculoskeletal ultrasound experts, the online course incorporates a comprehensive review of the sonographic appearance and recognition of upper and lo... |
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Anesthesiology Update 2024 - LIVE STREAMING or IN PERSON
The Comprehensive 2024 Anesthesiology Update
Cardiac, Regional, Office-Based, Thoracic, Obstetric, Neuro, and Pediatric
Anesthesiology Update will be held on May 6-10, 2024. You have the option to attend either online as the course is live streamed or in person in Boston, MA.
In the past year, there have been a number of very significant clinical changes that affect the practice of anesthesiology. This comprehensive CME program provides a special and timely opportunity for anesthesiolo... |
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A Class Act in Glaucoma Management: Differentiating Rho Kinase Inhibitors From the Pack
Medical management of glaucoma primarily focuses on lowering intraocular pressure (IOP) by decreasing aqueous production, reducing episcleral venous pressure, and/or increasing uveoscleral and trabecular outflow. Recently approved agents have expanded treatment options beyond the traditional mainstays of prostaglandin analogues and β-blockers, engaging Rho kinase (ROCK) inhibition to improve outcomes for patients with glaucoma. In this CE monograph, experts in the field will review the clinic... |
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Diabetes Update 2024 - LIVE STREAMING
This highly rated Harvard Medical School CME course offers practical strategies to address the medical and systemic challenges to optimal care and updates that ensure you can deliver state-of-the-art care for your patients with diabetes.
PROGRAM HIGHLIGHTS
This program affords you the opportunity to learn from leaders in the field of diabetes who are distinguished for their outstanding teaching, knowledge, and innovations in clinical care.
Participants can rely on this program for compreh... |
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The HIV Journey Staying the Course Through Critical Junctions in Care
HIV is a life-long condition that is becoming increasingly complex. Clinicians must be prepared to face myriad situations over a patient’s lifespan, relating both to their HIV and to either other comorbidities or issues such as stigma or social determinants of health. In this interactive activity, you will follow a patient diagnosed as an adolescent through his lifespan with HIV to make decisions about common challenges. Dr. Onyema Ogbuagu will review rapid ART, educating adolescents, addres... |
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Eosinophilic Esophagitis: Experts Address Your Burning Questions
Eosinophilic esophagitis (EoE) is a chronic type 2 helper (Th2)-mediated inflammatory disorder that is characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. Once considered rare, EoE is a relatively new disease that is now commonplace and affects both children and adults. When left unmanaged, EoE can impact a patient’s ability to eat properly, leading to food impaction and increased medical expenses. Recent data indicate that many c... |
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Case Challenges in nAMD and DME Management: Achieving Durable Response
The management of diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD) with intravitreal anti-vascular endothelial growth factor (VEGF) therapies has provided enhanced visual outcomes for many patients. However, the high treatment burden associated with anti-VEGF therapies can lead to lack of patient adherence, resulting in suboptimal outcomes. Personalized treatment protocols using FDA-approved agents and newer novel delivery systems, along with agents with uni... |
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Optimizing Transition from Pediatric to Adult Care - LIVE STREAMING
In this special program, faculty from Harvard Medical School, the Brigham Transition Care Team, and the Boston Children’s Hospital BRIDGES Adult Transition Program provide strategies, best practices, and guidance to:
• Identify adult care providers and successfully transfer patients with rare or complex health care needs
• Assess and improve the efficacy of your current transition processes
• Tailor transition strategies to patient age, disease type, and physical/ intellectual capab... |
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Innovations and New Practices in Internal Medicine 2024 -LIVE STREAMING
The State of the Art in Internal Medicine
This program, which is among the highest-rated Harvard Medical School CME courses, provides a comprehensive update of the most important changes now impacting Internal Medicine and guidance on how to incorporate these changes into your clinical practice to improve patient outcomes..
Practical, Fast-Paced, Online Education
This live streaming educational experience is fast paced, relevant to the current healthcare environment, and draws upon real... |
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Sports Medicine 2024 -LIVE STREAMING
The Comprehensive 2024 Sports Medicine Update
State-of-the-Art Approaches to the Diagnosis, Treatment, Rehabilitation, and Prevention of Sports Injuries
This Harvard Medical School CME program, which is among the highest-rated HMS CME courses, provides a special and timely opportunity to hear directly from world-renowned physician specialists (physiatrists, orthopedists, radiologists), team physicians and athletic trainers for the Boston Red Sox, New England Revolution, and New England P... |
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NeuroRehabilitation 2024 - LIVE STREAMING
Comprehensive Neurorehabilitation Update
Cutting-edge strategies, updates, and best practices for state-of-the-art rehabilitation
In this course, which is among the highest-rated Harvard Medical School CME courses, many of the country’s most experienced and committed neurorehabilitation experts will present cutting-edge clinical interventions, the latest findings, practical education, and hands-on methods to further your expertise in guiding your patients with stroke, SCI, TBI, brain t... |
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Introduction to Abdominal and Primary Care Ultrasound - Blended
The Blended Introduction to Abdominal & Primary Care Ultrasound course will give you a strong foundation to begin performing and/or interpreting abdominal and point-of-care ultrasound. The Blended Education format provides flexibility while saving you time and minimizing travel costs.
Begin with the self-paced online course: Taught by leading abdominal and primary care ultrasound experts, the comprehensive online course covers liver, gallbladder/biliary tree, renal/bladder, pancreas, sp... |
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Meeting Milestones in nAMD and DME Management: What's New?
Anti-vascular endothelial growth factor (VEGF) therapy has revolutionized treatment paradigms for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). However, these agents are associated with a high treatment burden because of the injection frequency, and a substantial number of patients do not adhere to their treatment schedules, resulting in suboptimal response to therapy. To address these issues, new dosage regimens and surgical drug delivery approaches hav... |
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WEBINAR: Metronomic Chemotherapy: Hope vs. Hype
Metronomic chemotherapy has become quite popular with oncologists and general practitioners. There are some basic scientific data addressing its mechanism of action, however, the vast amount of data is purely retrospective in nature. These studies vary in drug dosage and protocols used making assessment between studies challenging. On top of this, there are no good surrogate markers for efficacy to help guide clinicians. Last, the use of metronomic therapy has opened our eyes to the challenges... |
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Graft vs Host Disease: Novel Management Strategies for a Chronic Condition
Target Audience
The intended audience for this activity is transplant specialists, oncologists, hematologists, and other healthcare professionals involved in the treatment of patients with GVHD.
Program Overview
This enduring activity takes learners on a compelling journey in managing chronic graft-versus-host disease (cGVHD) by explaining the evidence-based diagnostic criteria for cGVHD for prompt diagnosis; discussing the clinical safety and efficacy data of recently approved and invest... |
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A Breath of Fresh Air: Novel Treatments That Address the Inflammatory Component of Non-Cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis (NCFBE) is a heterogenous and increasingly prevalent chronic pulmonary disease that is associated with high morbidity and mortality. It is characterized by irreversibly damaged and dilated bronchi, and has a broad spectrum of clinical presentations, ranging from asymptomatic radiological changes detected incidentally to chronic sputum production and recurrent exacerbations. There are numerous etiologies that can induce or contribute to the pathophysiological ... |
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In Case You Missed: Utilizing the Muscarinic System to Optimize Treatment Options for Schizophrenia
Schizophrenia is an incurable, neuropsychiatric disease characterized by difficulties thinking and communicating clearly as well as psychosis (ie, “positive” symptoms); difficulty functioning socially (ie, “negative” symptoms); and cognitive impairment. As many as 34% of patients with schizophrenia have treatment-resistant schizophrenia, defined as continuing symptoms despite at least 2 trials of appropriate antipsychotic treatment, and most people do not recover from it. Patients with... |
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The Pharmacist’s Role in Managing Patients with Worsening Heart Failure
Pharmacists play a vital role in the management of patients with heart failure (HF). Navigate through this interactive self-directed, pharmacist-targeted activity designed to optimize your decision-making to apply the most recent clinical trial data and guidance seen in real-world HF practice, particularly in patients with worsening HF and after recent HF hospitalization. Expert perspectives and insights cover guideline-directed medical therapy (GDMT) implementation and additional adjustment t... |
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28th Annual Hypertension, Diabetes & Dyslipidemia Conference
This three day intensive conference, held on June 19-21, 2024 in Charleston, South Carolina, addresses all the issues confronting clinicians who treat challenging patients with diabetes, hypertension, and dyslipidemia and how to apply this knowledge to everyday practice.
Over the past several years controversies in the appropriate target for Hemoglobin A1C, BP, and LDL-Cholesterol on outcome improvement continue to occur in Type 2 diabetes, Hypertension, and Dyslipidemia, respectively. Desp... |
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Diagnosis and Management of Patients With Predominant Skin Symptoms
The educational design of this activity addresses the needs of allergy/clinical immunology, gastroenterology, dermatology, and hematology clinicians who manage patients with nonadvanced systemic mastocytosis.
Nonadvanced systemic mastocytosis (SM) is a group of rare disorders characterized by mast cell accumulation that results in a significant and varied symptomatic burden to the patient. The most prevalent of these symptoms include gastrointestinal symptoms, dermatological symptoms, and ... |
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Managing Thyroid Eye Disease: Rapid Response From ENDO
For a timely diagnosis and optimal management of thyroid eye disease (TED), a multidisciplinary team of endocrinologists, ophthalmologists, oculoplastic surgeons, as well as other healthcare professionals is essential. Early diagnosis of TED through imaging and clinical assessment is imperative to allow for the timely initiation of therapeutic strategies that limit disfiguration and reduce the potential for vision loss. The recent updates to guidelines for the management of TED, along with the... |
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Answering the Call in Severe Asthma Expanding Roles for Biologic Treatment Regimens
This enduring Call-a-Colleague™ educational program will guide attendees through the long-term management of severe asthma. Expert faculty will provide actionable recommendations on evaluation strategies that consider underlying mechanism of disease, data on newer biologic treatment options, and most importantly, the use of these therapies in current day practice. Interspersed throughout the program are brief Call-a-Colleague™ video calls in which faculty consult with their specialist coll... |
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HIV Snippets " A Podcast Series: Optimizing Care in HIV Treatment and Prevention
Antiretroviral therapy (ART) for treating HIV has improved dramatically over the past decade. This progress has yielded more treatment choices for clinicians and patients but also adds greater complexity to the already-diverse field of HIV treatment. In this CE activity, participants will listen to expert faculty in a series of 4 podcasts. The faculty will explore various aspects of HIV management, including geographic disparities in pre-exposure prophylaxis (PrEP) implementation, use of 3-dru... |
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Major Depressive Disorder & Postpartum Depression: Targeting the GABA Deficit
Major depressive disorder (MDD), perinatal depression, and postpartum depression (PPD) are increasingly prevalent conditions that carry an extremely high disease burden. Underdiagnosis and undertreatment of major depressive episodes have led to significant unmet needs for these patient populations. Success of treatment with traditional antidepressants that target monoaminergic deficiencies and imbalances is limited by non- or incomplete therapeutic response as well as delayed onset of action. ... |
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Navigating New Evidence in the Treatment of HER2-Expressing Metastatic Breast Cancer in Rural and Underserved Communities
Target Audience
This activity is designed specifically for oncologists, advanced practice providers, and other members of the healthcare team who serve patients from rural and underserved communities.
Program Overview
Over the past decades, the emergence of novel targeted therapies in combination with endocrine therapy has improved outcomes for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. However, oncology clinicians in rural and ... |
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Gastroenterology 2024 - LIVE STREAMING
The Comprehensive 2024 Gastroenterology Update
This highly rated Harvard Medical School CME program ensures participants are current with state-of-the-art GI strategies and clinical practices. It covers recent advances and their impact on clinical approaches and on patient outcomes. Updates, best practices, and new guidelines are presented by nationally recognized GI experts and master clinicians.
Practical, Results-Driven Education
Highlights of the 2024 program include:
• Updated... |
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Internal Medicine Comprehensive Review and Update 2024 - LIVE STREAMING
Comprehensive, Evidence-Based Updates for Internal Medicine and Its Subspecialties
This program, the 64th annual Internal Medicine Update from the leading clinical faculty of Harvard Medical School and Massachusetts General Hospital, provides comprehensive, high-yield instruction to ensure clinicians are current with the latest evidence and best practices to optimize patient care.
This program covers the breadth of Internal Medicine subspecialties, including:
• Cardiovascular Medicine
... |
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Treating Obesity 2024: The Blackburn Course in Obesity Medicine - LIVE STREAMING
Education to Optimize Your Care of Adult, Adolescent, and Pediatric Patients with Obesity
This highly rated Harvard Medical School CME course delivers practical strategies to optimize the management of obesity and its many complications, and provides the most up-to-date approaches to obesity prevention and treatment.
Highlights of the 2024 program include:
• Update on using the newer GLP-1 based therapies
• Comprehensive evaluation of the patient with obesity
• Emerging precision me... |
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Lifestyle Medicine: Tools for Promoting Healthy Change - LIVE STREAMING
State-of-the-Art Approaches to Help Patients Initiate and Sustain Health-Promoting Behaviors
Lifestyle Medicine will be held online this year, using live streaming, electronic Q&A, and other remote learning technologies.
Overview
This immersive two-day course offers state-of-the-art strategies to guide patients to healthier lives. Education includes evidence-based strategies, tools and techniques to effect healthier changes in patients (and ourselves), including weight loss, exerci... |
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Combating the Stigma of Opioid Addiction
This webinar will address the stigma of addiction and how that effects people with substance use disorders. Experts will discuss the ways in which stigma serves as a barrier to effective prevention, treatment and recovery and highlight resources available to help overcome it and begin to break down this stigma in society. |
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Call to Action for Health Equity: Racial Disparities in the Care of Patients with Cardiometabolic Disease
Cardiovascular disease is the leading cause of death for adults in the US. However, patients from minority populations with cardiovascular disease have disproportionately poor health outcomes and are particularly vulnerable to health disparities. Racial inequities in health also result in higher risk-burden in minority groups for metabolic syndromes such as Type 2 (adult-onset) diabetes, which increase the risk of cardiovascular disease. Health disparities in cardiometabolic care predominantly... |
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Reducing Risks in Asthma: Mucus Plugs and Airway Obstruction
Target Audience
The educational design of this activity addresses the needs of pulmonology and clinical immunology clinicians who manage patients with severe asthma who are at risk for mucus plugs.
Program Overview
This Point-of-Care 201 program has been designed to educate and promote critical thinking through a discussion-based format that is accompanied by 3-dimensional animation. Expert faculty examine various sides of key clinical issues in asthma"including exploration of the pa... |
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Making the Call in Nonadvanced Systemic Mastocytosis Optimizing Multidisciplinary Management
Series Overview
Nonadvanced systemic mastocytosis (SM) is a group of rare disorders characterized by mast cell accumulation that results in a significant and varied symptomatic burden to the patient. The most prevalent of these symptoms include gastrointestinal symptoms, dermatological symptoms, and recurrent anaphylaxis in response to a variety of triggers such as food, insect venom, and medications. In this Phone-a-Friend series, a multidisciplinary panel of faculty experts will address the... |
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Rheumatology 101 for the Primary Care Clinician
The Pacific Northwest is experiencing a critical shortage of rheumatologists. Despite efforts from multiple organizations, including the American College of Rheumatology, The Arthritis Foundation, The University of Washington, and Virginia Mason Medical Center, Washington State continues to rank near the bottom for access issues. In a May 2022 interview, Washington Rheumatology Alliance (WRA) President Jeff Peterson, MD noted with concern that rural patients are particularly underserved, with ... |
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Applying Guidelines and Latest Evidence to the Management of Moderate‐to‐Severe Asthma in Children and Adults
Target Audience
The educational design of this activity addresses the needs of pulmonologists, allergists/immunologists, NPs and PAs, and other clinicians involved in the management of patients with moderate‐to‐severe asthma.
Program Overview
Patients with asthma and underlying comorbidities require personalized treatment to achieve asthma control. Children with asthma have an especially high burden of symptoms, and are at risk of impaired lung development if asthma control cannot be ... |
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TOP 10 Early Cancer Detection Queries What You Need to Know About Blood-Based Screening in Primary Care
In this “Top 10 Early Cancer Detection Queries” program, Dr. Mylynda Massart answers the 10 questions most commonly asked by primary care clinicians about blood-based multi-cancer early detection (MCED) tests. Some of the topics addressed are the science behind MCEDs, their accuracy, how MCEDs compare to other screening modalities, and integration of MCED testing into primary care practice. |
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The PrEP Journey Charting the Course Through HIV Prevention
HIV prevention with preexposure prophylaxis (PrEP) is an essential tool for clinicians to help end the HIV epidemic. In this case-based interactive activity, you will learn the basics of assessing HIV risk, conversing with patients about sexual health, and providing PrEP, from initiation to monitoring and follow-up. Then, more challenging cases will illustrate the nuances of providing PrEP based on patient characteristics and preferences. Prof Daniel Richardson and nurse practitioner Shauna Ap... |
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FOP: Enhancing Diagnosis and Management to Improve Patients’ Quality of Life
Target Audience
The educational design of this activity addresses the needs of the primary audience of orthopedists, bone specialists, rheumatologists, pediatric rheumatologists, and genetic counselors, and the secondary audience of PCPs, pediatricians, dermatologists, endocrinologists, occupational therapists, oncologists, general practice NPs and PAs, and specialist NPs and PAs.
Program Overview
Because fibrodysplasia ossificans progressiva, or FOP, is exceedingly rare, even specialists... |
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Dialogues about FOP: What Patients Wish More Doctors Knew to Enhance Early Recognition and Management
Target Audience
The educational design of this activity addresses the needs of the primary audience of PCPs, pediatricians, dermatologists, endocrinologists, occupational therapists, oncologists, general practice NPs and PAs, specialist NPs and PAs, and the secondary audience of orthopedists, bone specialists, rheumatologists, pediatric rheumatologists, genetic counselors, and dentists.
Statement of Need/Program Overview
Fibrodysplasia ossificans progressiva (FOP) causes abnormal bone for... |
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